BACKGROUND: This paper aims to evaluate, in a clinical context, current creatinine-based formulas commonly used to calculate renal function in morbidly obese patients. METHODS: A retrospective analysis was performed of the estimates of renal function of 63 obese or morbidly obese patients undergoing gastric bypass surgery. Each patient's glomerular filtration rate (GFR) was calculated using five methods, both before and after surgery, and these approximations were then compared. RESULTS: Prior to surgery, the values offered by the five formulas for the renal function of this population ranged widely, by over a factor of 2. After surgery, the three weight-based GFR estimation methods indicated that a significant change in GFR had occurred, but the two non-weight-based formulas showed no significant change in estimated GFR. CONCLUSIONS: At baseline and after significant weight loss, creatinine-based formulas differ twofold in their estimates of renal function of the morbidly obese. An accurate method for calculating these patients' renal function is required to improve patient safety with drug dosing as well as to ensure early detection of renal failure.
BACKGROUND: This paper aims to evaluate, in a clinical context, current creatinine-based formulas commonly used to calculate renal function in morbidly obesepatients. METHODS: A retrospective analysis was performed of the estimates of renal function of 63 obese or morbidly obesepatients undergoing gastric bypass surgery. Each patient's glomerular filtration rate (GFR) was calculated using five methods, both before and after surgery, and these approximations were then compared. RESULTS: Prior to surgery, the values offered by the five formulas for the renal function of this population ranged widely, by over a factor of 2. After surgery, the three weight-based GFR estimation methods indicated that a significant change in GFR had occurred, but the two non-weight-based formulas showed no significant change in estimated GFR. CONCLUSIONS: At baseline and after significant weight loss, creatinine-based formulas differ twofold in their estimates of renal function of the morbidly obese. An accurate method for calculating these patients' renal function is required to improve patient safety with drug dosing as well as to ensure early detection of renal failure.
Authors: Jorge L Zelada Getty; Isam N Hamdallah; Hazem N Shamseddeen; Jennifer Wu; Roger K Low; Jacqueline Craig; Mohamed R Ali Journal: Obes Surg Date: 2012-07 Impact factor: 4.129
Authors: Robyn A Tamboli; H Ayesha Hossain; Pamela A Marks; Aaron W Eckhauser; John A Rathmacher; Sharon E Phillips; Maciej S Buchowski; Kong Y Chen; Naji N Abumrad Journal: Obesity (Silver Spring) Date: 2010-04-22 Impact factor: 5.002
Authors: Joshua R Lewis; Wai Lim; Satvinder S Dhaliwal; Kun Zhu; Ee Mun Lim; Peter L Thompson; Richard L Prince Journal: BMC Nephrol Date: 2012-07-16 Impact factor: 2.388
Authors: Daniela S C Magalhães; Jorge M P Pedro; Pedro E B Souteiro; João Sérgio Neves; Sofia Castro-Oliveira; Rita Bettencourt-Silva; Maria Manuel Costa; Ana Varela; Joana Queirós; Paula Freitas; Davide Carvalho Journal: Obes Surg Date: 2019-01 Impact factor: 4.129