Literature DB >> 20571506

Genes predict village of origin in rural Europe.

Colm O'Dushlaine1, Ruth McQuillan, Michael E Weale, Daniel J M Crouch, Asa Johansson, Yurii Aulchenko, Christopher S Franklin, Ozren Polašek, Christian Fuchsberger, Aiden Corvin, Andrew A Hicks, Veronique Vitart, Caroline Hayward, Sarah H Wild, Thomas Meitinger, Cornelia M van Duijn, Ulf Gyllensten, Alan F Wright, Harry Campbell, Peter P Pramstaller, Igor Rudan, James F Wilson.   

Abstract

The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30  km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.

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Year:  2010        PMID： 20571506      PMCID： PMC2987479          DOI： 10.1038/ejhg.2010.92

Source DB:  PubMed          Journal:  Eur J Hum Genet        ISSN： 1018-4813            Impact factor:   4.246


  11 in total

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Journal:  Am J Hum Genet       Date:  2008-08-28       Impact factor: 11.025

5.  Worldwide human relationships inferred from genome-wide patterns of variation.

Authors:  Jun Z Li; Devin M Absher; Hua Tang; Audrey M Southwick; Amanda M Casto; Sohini Ramachandran; Howard M Cann; Gregory S Barsh; Marcus Feldman; Luigi L Cavalli-Sforza; Richard M Myers
Journal:  Science       Date:  2008-02-22       Impact factor: 47.728

6.  Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

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Journal:  Nat Genet       Date:  2008-03-09       Impact factor: 38.330

9.  Population structure and eigenanalysis.

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Journal:  PLoS One       Date:  2009-05-08       Impact factor: 3.240
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  14 in total

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2.  North Africans traveling north.

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3.  Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity.

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4.  Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism data.

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5.  Fine-scale human genetic structure in Western France.

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6.  Tales the double helix tells.

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Journal:  Investig Genet       Date:  2010-09-01

7.  Cryptic distant relatives are common in both isolated and cosmopolitan genetic samples.

Authors:  Brenna M Henn; Lawrence Hon; J Michael Macpherson; Nick Eriksson; Serge Saxonov; Itsik Pe'er; Joanna L Mountain
Journal:  PLoS One       Date:  2012-04-03       Impact factor: 3.240

8.  Geographic population structure analysis of worldwide human populations infers their biogeographical origins.

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