BACKGROUND: Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results. METHODS: We pooled individual-level data from nine case-control studies of head and neck cancers, including 5,139 cases and 9,028 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for potential confounders. RESULTS: Caffeinated coffee intake was inversely related with the risk of cancer of the oral cavity and pharynx: the ORs were 0.96 (95% CI, 0.94-0.98) for an increment of 1 cup per day and 0.61 (95% CI, 0.47-0.80) in drinkers of >4 cups per day versus nondrinkers. This latter estimate was consistent for different anatomic sites (OR, 0.46; 95% CI, 0.30-0.71 for oral cavity; OR, 0.58; 95% CI, 0.41-0.82 for oropharynx/hypopharynx; and OR, 0.61; 95% CI, 0.37-1.01 for oral cavity/pharynx not otherwise specified) and across strata of selected covariates. No association of caffeinated coffee drinking was found with laryngeal cancer (OR, 0.96; 95% CI, 0.64-1.45 in drinkers of >4 cups per day versus nondrinkers). Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk. Tea intake was not associated with head and neck cancer risk (OR, 0.99; 95% CI, 0.89-1.11 for drinkers versus nondrinkers). CONCLUSIONS: This pooled analysis of case-control studies supports the hypothesis of an inverse association between caffeinated coffee drinking and risk of cancer of the oral cavity and pharynx. IMPACT: Given widespread use of coffee and the relatively high incidence and low survival of head and neck cancers, the observed inverse association may have appreciable public health relevance.
BACKGROUND: Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results. METHODS: We pooled individual-level data from nine case-control studies of head and neck cancers, including 5,139 cases and 9,028 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for potential confounders. RESULTS:Caffeinated coffee intake was inversely related with the risk of cancer of the oral cavity and pharynx: the ORs were 0.96 (95% CI, 0.94-0.98) for an increment of 1 cup per day and 0.61 (95% CI, 0.47-0.80) in drinkers of >4 cups per day versus nondrinkers. This latter estimate was consistent for different anatomic sites (OR, 0.46; 95% CI, 0.30-0.71 for oral cavity; OR, 0.58; 95% CI, 0.41-0.82 for oropharynx/hypopharynx; and OR, 0.61; 95% CI, 0.37-1.01 for oral cavity/pharynx not otherwise specified) and across strata of selected covariates. No association of caffeinated coffee drinking was found with laryngeal cancer (OR, 0.96; 95% CI, 0.64-1.45 in drinkers of >4 cups per day versus nondrinkers). Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk. Tea intake was not associated with head and neck cancer risk (OR, 0.99; 95% CI, 0.89-1.11 for drinkers versus nondrinkers). CONCLUSIONS: This pooled analysis of case-control studies supports the hypothesis of an inverse association between caffeinated coffee drinking and risk of cancer of the oral cavity and pharynx. IMPACT: Given widespread use of coffee and the relatively high incidence and low survival of head and neck cancers, the observed inverse association may have appreciable public health relevance.
Authors: David I Conway; Mia Hashibe; Paolo Boffetta; Victor Wunsch-Filho; Joshua Muscat; Carlo La Vecchia; Deborah M Winn Journal: Oral Oncol Date: 2009-05-12 Impact factor: 5.337
Authors: Pagona Lagiou; Renato Talamini; Evangelia Samoli; Areti Lagiou; Wolfgang Ahrens; Hermann Pohlabeln; Simone Benhamou; Christine Bouchardy; Alena Slamova; Miriam Schejbalova; Franco Merletti; Lorenzo Richiardi; Kristina Kjaerheim; Antonio Agudo; Xavier Castellsague; Tatiana V Macfarlane; Gary J Macfarlane; Anne-Marie Biggs; Luigi Barzan; Cristina Canova; Lorenzo Simonato; Raymond J Lowry; David I Conway; Patricia A McKinney; Ariana Znaor; Bernard E McCartan; Claire M Healy; Manuela Marron; Mia Hashibe; Paul Brennan Journal: Int J Cancer Date: 2009-06-01 Impact factor: 7.396
Authors: Julia E Heck; Amir Sapkota; Gajalakshmi Vendhan; Soma Roychowdhury; Rajesh P Dikshit; Dhaval H Jetly; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Cancer Causes Control Date: 2008-08-13 Impact factor: 2.506
Authors: Marta Rossi; Werner Garavello; Renato Talamini; Eva Negri; Cristina Bosetti; Luigino Dal Maso; Pagona Lagiou; Alessandra Tavani; Jerry Polesel; Luigi Barzan; Valerio Ramazzotti; Silvia Franceschi; Carlo La Vecchia Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-08 Impact factor: 4.254
Authors: Brandilyn A Peters; Marjorie L McCullough; Mark P Purdue; Neal D Freedman; Caroline Y Um; Susan M Gapstur; Richard B Hayes; Jiyoung Ahn Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-04-27 Impact factor: 4.254
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Werner Garavello; Diego Serraino; Carlo La Vecchia Journal: Int J Cancer Date: 2017-05-09 Impact factor: 7.396
Authors: David J Cote; Alaina M Bever; Kathryn M Wilson; Timothy R Smith; Stephanie A Smith-Warner; Meir J Stampfer Journal: Int J Cancer Date: 2019-07-26 Impact factor: 7.396
Authors: Carlotta Galeone; Federica Turati; Zuo-Feng Zhang; Valentina Guercio; Alessandra Tavani; Diego Serraino; Paul Brennan; Eleonora Fabianova; Jola Lissowska; Dana Mates; Peter Rudnai; Oxana Shangina; Neonila Szeszenia-Dabrowska; Thomas L Vaughan; Karl Kelsey; Michael McClean; Fabio Levi; Richard B Hayes; Mark P Purdue; Cristina Bosetti; Hermann Brenner; Claudio Pelucchi; Yuan-Chin Amy Lee; Mia Hashibe; Paolo Boffetta; Carlo La Vecchia Journal: Mol Nutr Food Res Date: 2015-07-02 Impact factor: 5.914
Authors: Yuan-Chin Amy Lee; Mohammed Al-Temimi; Jian Ying; Joshua Muscat; Andrew F Olshan; Jose P Zevallos; Deborah M Winn; Guojun Li; Erich M Sturgis; Hal Morgenstern; Zuo-Feng Zhang; Elaine Smith; Karl Kelsey; Michael McClean; Thomas L Vaughan; Philip Lazarus; Chu Chen; Stephen M Schwartz; Maura Gillison; Stimson Schantz; Guo-Pei Yu; Gypsyamber D'Souza; Neil Gross; Marcus Monroe; Jaewhan Kim; Paolo Boffetta; Mia Hashibe Journal: Am J Epidemiol Date: 2020-04-02 Impact factor: 4.897
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Diego Serraino; Carlo La Vecchia Journal: Cancer Causes Control Date: 2016-07-05 Impact factor: 2.506