OBJECTIVE: The Indian subcontinent has among the highest rates of hypopharyngeal cancer worldwide. The purpose of this study was to examine the associations between the Indian diet and hypopharyngeal cancer. METHODS: We used data from a hospital-based case-control study of 513 incident hypopharyngeal cancers and 718 controls from four centers in India. Dietary information was assessed using a 67-item semi-quantitative food frequency questionnaire. Intakes of related foods were combined across food groups and were categorized by quartile. We used unconditional logistic regression modeling, stratified by ever tobacco use, to analyze the association between food intakes and hypopharyngeal cancer. RESULTS: Among persons who had ever smoked or chewed tobacco, protective associations were seen at the highest quartiles of total fruit intake (OR = 0.37, 0.20-0.69), curds (OR = 0.35, 0.17-0.69), and leafy green (OR = 0.25, 95% CI 0.13-0.51), root (OR = 0.22, 95% CI 0.11-0.43), and cruciferous vegetable intakes (OR = 0.41, 0.20-0.84). Results were similar, although not as robust, among persons who had never smoked or chewed tobacco. An increased risk of disease was seen among tobacco users who drank milk daily (OR = 1.84, 1.14-2.98). CONCLUSIONS: Dietary factors might contribute to the high risk of hypopharyngeal cancer observed in India.
OBJECTIVE: The Indian subcontinent has among the highest rates of hypopharyngeal cancer worldwide. The purpose of this study was to examine the associations between the Indian diet and hypopharyngeal cancer. METHODS: We used data from a hospital-based case-control study of 513 incident hypopharyngeal cancers and 718 controls from four centers in India. Dietary information was assessed using a 67-item semi-quantitative food frequency questionnaire. Intakes of related foods were combined across food groups and were categorized by quartile. We used unconditional logistic regression modeling, stratified by ever tobacco use, to analyze the association between food intakes and hypopharyngeal cancer. RESULTS: Among persons who had ever smoked or chewed tobacco, protective associations were seen at the highest quartiles of total fruit intake (OR = 0.37, 0.20-0.69), curds (OR = 0.35, 0.17-0.69), and leafy green (OR = 0.25, 95% CI 0.13-0.51), root (OR = 0.22, 95% CI 0.11-0.43), and cruciferous vegetable intakes (OR = 0.41, 0.20-0.84). Results were similar, although not as robust, among persons who had never smoked or chewed tobacco. An increased risk of disease was seen among tobacco users who drank milk daily (OR = 1.84, 1.14-2.98). CONCLUSIONS: Dietary factors might contribute to the high risk of hypopharyngeal cancer observed in India.
Authors: Carlotta Galeone; Alessandra Tavani; Claudio Pelucchi; Federica Turati; Deborah M Winn; Fabio Levi; Guo-Pei Yu; Hal Morgenstern; Karl Kelsey; Luigino Dal Maso; Mark P Purdue; Michael McClean; Renato Talamini; Richard B Hayes; Silvia Franceschi; Stimson Schantz; Zuo-Feng Zhang; Gilles Ferro; Shu-Chun Chuang; Paolo Boffetta; Carlo La Vecchia; Mia Hashibe Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-06-22 Impact factor: 4.254
Authors: Julia E Heck; Julien Berthiller; Salvatore Vaccarella; Deborah M Winn; Elaine M Smith; Oxana Shan'gina; Stephen M Schwartz; Mark P Purdue; Agnieszka Pilarska; Jose Eluf-Neto; Ana Menezes; Michael D McClean; Elena Matos; Sergio Koifman; Karl T Kelsey; Rolando Herrero; Richard B Hayes; Silvia Franceschi; Victor Wünsch-Filho; Leticia Fernández; Alexander W Daudt; Maria Paula Curado; Chu Chen; Xavier Castellsagué; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Int J Epidemiol Date: 2009-12-18 Impact factor: 7.196
Authors: Julia E Heck; Jeri W Nieves; Yu Chen; Faruque Parvez; Paul W Brandt-Rauf; Geoffrey R Howe; Habibul Ahsan Journal: Food Nutr Bull Date: 2010-06 Impact factor: 2.069
Authors: Qian Li; Shu-Chun Chuang; Jose Eluf-Neto; Ana Menezes; Elena Matos; Sergio Koifman; Victor Wünsch-Filho; Leticia Fernandez; Alexander W Daudt; Maria Paula Curado; Deborah M Winn; Silvia Franceschi; Rolando Herrero; Xavier Castellsague; Hal Morgenstern; Zuo-Feng Zhang; Philip Lazarus; Joshua Muscat; Michael McClean; Karl T Kelsey; Richard B Hayes; Mark P Purdue; Stephen M Schwartz; Chu Chen; Simone Benhamou; Andrew F Olshan; Guopei Yu; Stimson Schantz; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Int J Cancer Date: 2012-01-27 Impact factor: 7.396
Authors: Rashmi Sinha; Carrie R Daniel; Niveditha Devasenapathy; Hemali Shetty; Susan Yurgalevitch; Leah M Ferrucci; Preethi S George; Kerry Grace Morrissey; Lakshmy Ramakrishnan; Barry I Graubard; Kavita Kapur; K Srinath Reddy; Mary J McAdams; Tanuja Rastogi; Nilanjan Chatterjee; Prakash C Gupta; Sholom Wacholder; Dorairaj Prabhakaran; Aleyamma A Mathew Journal: BMC Public Health Date: 2011-05-27 Impact factor: 3.295
Authors: Julia E Heck; Angeline S Andrew; Tracy Onega; James R Rigas; Brian P Jackson; Margaret R Karagas; Eric J Duell Journal: Environ Health Perspect Date: 2009-07-02 Impact factor: 9.031
Authors: Julia E Heck; Jeri W Nieves; Yu Chen; Faruque Parvez; Paul W Brandt-Rauf; Joseph H Graziano; Vesna Slavkovich; Geoffrey R Howe; Habibul Ahsan Journal: Environ Health Perspect Date: 2008-08-22 Impact factor: 9.031