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Literature DB >> 26920876

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.

Sarah Höfs¹, Selene Mogavero¹, Bernhard Hube^2,3,4.

Abstract

The interaction between Candida albicans and its host cells is characterized by a complex interplay between the expression of fungal virulence factors, which results in adherence, invasion and cell damage, and the host immune system, which responds by secreting proinflammatory cytokines, activating antimicrobial activities and killing the fungal pathogen. In this review we describe this interplay by taking a closer look at how C. albicans pathogenicity is induced and executed, how the host responds in order to prevent and clear an infection, and which mechanisms C. albicans has evolved to bypass these immune responses to avoid clearance. Furthermore, we review studies that show how the presence of other microorganisms affects this interplay.

Entities: Disease Species

Keywords: adhesion; biofilm; fungal infection; fungal-bacterial interactions; host response; morphogenesis

Mesh：

Substances：
Virulence Factors

Year: 2016 PMID： 26920876 DOI： 10.1007/s12275-016-5514-0

Source DB: PubMed Journal: J Microbiol ISSN： 1225-8873 Impact factor: 3.422

276 in total

Review 1. Growth of Candida albicans hyphae.

Authors: Peter E Sudbery
Journal: Nat Rev Microbiol Date: 2011-08-16 Impact factor: 60.633

Review 2. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans.

Authors: Shanshan Luo; Christine Skerka; Oliver Kurzai; Peter F Zipfel
Journal: Mol Immunol Date: 2013-06-26 Impact factor: 4.407

3. Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5p.

Authors: Jason M Rauceo; Richard De Armond; Henry Otoo; Peter C Kahn; Stephen A Klotz; Nand K Gaur; Peter N Lipke
Journal: Eukaryot Cell Date: 2006-08-25

4. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.

Authors: F Re; J L Strominger
Journal: J Biol Chem Date: 2001-07-26 Impact factor: 5.157

5. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.

Authors: J F Staab; S D Bradway; P L Fidel; P Sundstrom
Journal: Science Date: 1999-03-05 Impact factor: 47.728

6. Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells.

Authors: Jeanette Wagener; Günther Weindl; Piet W J de Groot; Albert D de Boer; Susanne Kaesler; Selvam Thavaraj; Oliver Bader; Daniela Mailänder-Sanchez; Claudia Borelli; Michael Weig; Tilo Biedermann; Julian R Naglik; Hans Christian Korting; Martin Schaller
Journal: PLoS One Date: 2012-11-30 Impact factor: 3.240

7. Host cell invasion and virulence mediated by Candida albicans Ssa1.

Authors: Jianing N Sun; Norma V Solis; Quynh T Phan; Jashanjot S Bajwa; Helena Kashleva; Angela Thompson; Yaoping Liu; Anna Dongari-Bagtzoglou; Mira Edgerton; Scott G Filler
Journal: PLoS Pathog Date: 2010-11-11 Impact factor: 6.823

8. Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages.

Authors: L Maródi; H M Korchak; R B Johnston
Journal: J Immunol Date: 1991-04-15 Impact factor: 5.422

9. Pseudomonas-Candida interactions: an ecological role for virulence factors.

Authors: Deborah A Hogan; Roberto Kolter
Journal: Science Date: 2002-06-21 Impact factor: 47.728

Review 10. Interactions of Candida albicans with host epithelial surfaces.

Authors: David W Williams; Rachael P C Jordan; Xiao-Qing Wei; Carlos T Alves; Matt P Wise; Melanie J Wilson; Michael A O Lewis
Journal: J Oral Microbiol Date: 2013-10-21 Impact factor: 5.474

68 in total

1. Human fungal pathogens: Why should we learn?

Authors: Jeong-Yoon Kim
Journal: J Microbiol Date: 2016-03 Impact factor: 3.422

2. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis.

Authors: Rodnei Dennis Rossoni; Marisol Dos Santos Velloso; Lívia Mara Alves Figueiredo; Carolina Pistille Martins; Antonio Olavo Cardoso Jorge; Juliana Campos Junqueira
Journal: Folia Microbiol (Praha) Date: 2017-11-23 Impact factor: 2.099

Review 3. CO₂ sensing in fungi: at the heart of metabolic signaling.

Authors: Ronny Martin; Susann Pohlers; Fritz A Mühlschlegel; Oliver Kurzai
Journal: Curr Genet Date: 2017-05-10 Impact factor: 3.886

4. Role of the Inducible Adhesin CpAls7 in Binding of Candida parapsilosis to the Extracellular Matrix under Fluid Shear.

Authors: Sunil K Shaw; Joseph M Bliss; Matthew N Neale; Kyle A Glass; Sarah J Longley; Denny J Kim; Sonia S Laforce-Nesbitt; Jeremy D Wortzel
Journal: Infect Immun Date: 2018-03-22 Impact factor: 3.441

5. Large-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions.

Authors: Jae Jung Kim; Eduardo Reátegui; Alex Hopke; Fatemeh Jalali; Maedeh Roushan; Patrick S Doyle; Daniel Irimia
Journal: Lab Chip Date: 2018-05-29 Impact factor: 6.799

6. Micafungin Enhances the Human Macrophage Response to Candida albicans through β-Glucan Exposure.

Authors: José Pedro Guirao-Abad; Ruth Sánchez-Fresneda; Francisco Machado; Juan Carlos Argüelles; María Martínez-Esparza
Journal: Antimicrob Agents Chemother Date: 2018-04-26 Impact factor: 5.191

7. The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies.

Authors: Jana Maršíková; Martina Pavlíčková; Derek Wilkinson; Libuše Váchová; Otakar Hlaváček; Ladislava Hatáková; Zdena Palková
Journal: Proc Natl Acad Sci U S A Date: 2020-06-15 Impact factor: 11.205

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.

Review 1. Growth of Candida albicans hyphae.

Review 2. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans.

3. Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5p.

4. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.

5. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.

6. Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells.

7. Host cell invasion and virulence mediated by Candida albicans Ssa1.

8. Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages.

9. Pseudomonas-Candida interactions: an ecological role for virulence factors.

Review 10. Interactions of Candida albicans with host epithelial surfaces.

1. Human fungal pathogens: Why should we learn?

2. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis.

Review 3. CO₂ sensing in fungi: at the heart of metabolic signaling.

4. Role of the Inducible Adhesin CpAls7 in Binding of Candida parapsilosis to the Extracellular Matrix under Fluid Shear.

5. Large-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions.

6. Micafungin Enhances the Human Macrophage Response to Candida albicans through β-Glucan Exposure.

7. The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies.

8. Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.

Review 9. Fungal interactions with the human host: exploring the spectrum of symbiosis.

Review 10. Neutrophil extracellular traps in fungal infection.

Review 1. Growth of Candida albicans hyphae.

Review 2. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans.

Review 10. Interactions of Candida albicans with host epithelial surfaces.

Review 3. CO2 sensing in fungi: at the heart of metabolic signaling.

Review 9. Fungal interactions with the human host: exploring the spectrum of symbiosis.

Review 10. Neutrophil extracellular traps in fungal infection.

Review 3. CO₂ sensing in fungi: at the heart of metabolic signaling.