Literature DB >> 29311061

Enhanced Efflux Pump Activity in Old Candida glabrata Cells.

Somanon Bhattacharya1, Bettina C Fries2,3.   

Abstract

We investigated the effect of replicative aging on antifungal resistance in Candida glabrata Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Candida glabrata; aging; antifungal resistance; drug resistance mechanisms; efflux pumps

Mesh：

Substances：

Year:  2018        PMID： 29311061      PMCID： PMC5826134          DOI： 10.1128/AAC.02227-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies.

Authors:  John-Paul Vermitsky; Kelly D Earhart; W Lamar Smith; Ramin Homayouni; Thomas D Edlind; P David Rogers
Journal:  Mol Microbiol       Date:  2006-06-27       Impact factor: 3.501

2.  The contribution of Saccharomyces cerevisiae replicative age to the variations in the levels of Trx2p, Pdr5p, Can1p and Idh isoforms.

Authors:  Aglaia V Azbarova; Kseniia V Galkina; Maxim I Sorokin; Fedor F Severin; Dmitry A Knorre
Journal:  Sci Rep       Date:  2017-10-16       Impact factor: 4.379

Review 3.  Azole Resistance in Candida glabrata.

Authors:  Sarah G Whaley; P David Rogers
Journal:  Curr Infect Dis Rep       Date:  2016-12       Impact factor: 3.725

4.  Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.

Authors:  Laura Y Young; Christina M Hull; Joseph Heitman
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

5.  Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms.

Authors:  C J Seneviratne; L J Jin; Y H Samaranayake; L P Samaranayake
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

6.  Expression of CgCDR1, CgCDR2, and CgERG11 in Candida glabrata biofilms formed by bloodstream isolates.

Authors:  Jeong Won Song; Jong Hee Shin; Seung Jung Kee; Soo Hyun Kim; Myung Geun Shin; Soon Pal Suh; Dong Wook Ryang
Journal:  Med Mycol       Date:  2009       Impact factor: 4.076

Review 7.  Drug:H+ antiporters in chemical stress response in yeast.

Authors:  Isabel Sá-Correia; Sandra C dos Santos; Miguel C Teixeira; Tânia R Cabrito; Nuno P Mira
Journal:  Trends Microbiol       Date:  2008-12-04       Impact factor: 17.079

8.  Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.

Authors:  Alaattin Kaya; Alexei V Lobanov; Vadim N Gladyshev
Journal:  Aging Cell       Date:  2015-02-22       Impact factor: 9.304

9.  Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.

Authors:  Danielly Beraldo dos Santos Silva; Luana Mireli Carbonera Rodrigues; Adriana Araújo de Almeida; Kelly Mari Pires de Oliveira; Alexéia Barufatti Grisolia
Journal:  Mem Inst Oswaldo Cruz       Date:  2016-03-15       Impact factor: 2.743

10.  Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR.

Authors:  Shadi Shahrokhi; Fatemeh Noorbakhsh; Sassan Rezaie
Journal:  Iran J Public Health       Date:  2017-08       Impact factor: 1.429
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  7 in total

Review 1.  Candidiasis and Mechanisms of Antifungal Resistance.

Authors:  Somanon Bhattacharya; Sutthichai Sae-Tia; Bettina C Fries
Journal:  Antibiotics (Basel)       Date:  2020-06-09

2.  Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age.

Authors:  Somanon Bhattacharya; Thomas Holowka; Erika P Orner; Bettina C Fries
Journal:  Sci Rep       Date:  2019-03-25       Impact factor: 4.379

3.  High-Throughput Yeast Aging Analysis for Cryptococcus (HYAAC) microfluidic device streamlines aging studies in Cryptococcus neoformans.

Authors:  Erika P Orner; Pengchao Zhang; Myeong C Jo; Somanon Bhattacharya; Lidong Qin; Bettina C Fries
Journal:  Commun Biol       Date:  2019-07-10

Review 4.  Replicative Aging in Pathogenic Fungi.

Authors:  Somanon Bhattacharya; Tejas Bouklas; Bettina C Fries
Journal:  J Fungi (Basel)       Date:  2020-12-25

5.  Replicative Aging Remodels the Cell Wall and Is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts.

Authors:  Vanessa K A Silva; Somanon Bhattacharya; Natalia Kronbauer Oliveira; Anne G Savitt; Daniel Zamith-Miranda; Joshua D Nosanchuk; Bettina C Fries
Journal:  mBio       Date:  2022-02-15       Impact factor: 7.867

6.  Cell Wall-Associated Virulence Factors Contribute to Increased Resilience of Old Cryptococcus neoformans Cells.

Authors:  Erika P Orner; Somanon Bhattacharya; Klea Kalenja; Danielle Hayden; Maurizio Del Poeta; Bettina C Fries
Journal:  Front Microbiol       Date:  2019-11-07       Impact factor: 5.640

7.  Candidiasis by Candida glabrata, Candida nivariensis and Candida bracarensis in Galleria mellonella: Virulence and Therapeutic Responses to Echinocandins.

Authors:  Ainara Hernando-Ortiz; Elena Eraso; Guillermo Quindós; Estibaliz Mateo
Journal:  J Fungi (Basel)       Date:  2021-11-23
  7 in total

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