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Literature DB >> 20485365

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia.

Maria Karayiorgou¹, Tony J Simon, Joseph A Gogos.

Abstract

Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20485365 PMCID： PMC2977984 DOI： 10.1038/nrn2841

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

183 in total

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204 in total

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