Literature DB >> 25910423

Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.

Andrew M Rosen1, Timothy Spellman2, Joshua A Gordon3.   

Abstract

Schizophrenia is caused by a diverse array of risk factors and results in a similarly diverse set of symptoms. Electrophysiological endophenotypes lie between risks and symptoms and have the potential to link the two. Electrophysiological studies in rodent models, described here, demonstrate that widely differing risk factors result in a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared neurobiological substrate.
Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  EEG; Excitation/inhibition balance; Local field potentials; Oscillations; Schizophrenia; Synaptic plasticity

Mesh：

Year:  2015        PMID： 25910423      PMCID： PMC4444383          DOI： 10.1016/j.biopsych.2015.03.021

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  130 in total

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