Literature DB >> 16736020

Canalization of development by microRNAs.

Eran Hornstein1, Noam Shomron.   

Abstract

Animal development is an extremely robust process resulting in stereotyped outcomes. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. Recent revelations into microRNA (miRNA) function suggest that miRNAs act as key players in canalizing genetic programs. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs.

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Year:  2006        PMID： 16736020     DOI： 10.1038/ng1803

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  272 in total

1.  MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.

Authors:  Chang-Il Hwang; Jinhyang Choi; Zongxiang Zhou; Andrea Flesken-Nikitin; Alexander Tarakhovsky; Alexander Yu Nikitin
Journal:  Cell Cycle       Date:  2011-11-15       Impact factor: 4.534

Review 2.  Evolution of microRNA diversity and regulation in animals.

Authors:  Eugene Berezikov
Journal:  Nat Rev Genet       Date:  2011-11-18       Impact factor: 53.242

3.  MicroRNAs: Novel Regulators of the Heart.

Authors:  Junjie Xiao; Yi-Han Chen
Journal:  J Thorac Dis       Date:  2010-03       Impact factor: 2.895

Review 4.  The limits of brain determinacy.

Authors:  Peter G H Clarke
Journal:  Proc Biol Sci       Date:  2012-02-01       Impact factor: 5.349

5.  "Hypothesis for the modern RNA world": a pervasive non-coding RNA-based genetic regulation is a prerequisite for the emergence of multicellular complexity.

Authors:  Irma Lozada-Chávez; Peter F Stadler; Sonja J Prohaska
Journal:  Orig Life Evol Biosph       Date:  2012-02-10       Impact factor: 1.950

6.  miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate.

Authors:  Mati Mann; Omer Barad; Reuven Agami; Benjamin Geiger; Eran Hornstein
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-18       Impact factor: 11.205

Review 7.  The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders.

Authors:  Liam J Drew; Gregg W Crabtree; Sander Markx; Kimberly L Stark; Florence Chaverneff; Bin Xu; Jun Mukai; Karine Fenelon; Pei-Ken Hsu; Joseph A Gogos; Maria Karayiorgou
Journal:  Int J Dev Neurosci       Date:  2010-10-08       Impact factor: 2.457

8.  Gene regulation and noise reduction by coupling of stochastic processes.

Authors:  Alexandre F Ramos; José Eduardo M Hornos; John Reinitz
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2015-02-26

9.  A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate.

Authors:  Shan Wang; Changsheng Sun; Yan Meng; Bing Zhang; Xin Wang; Yanguo Su; Lei Shi; Eryang Zhao
Journal:  Exp Ther Med       Date:  2017-03-21       Impact factor: 2.447

Review 10.  Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis.

Authors:  Deepika Neelakantan; David J Drasin; Heide L Ford
Journal:  Cell Adh Migr       Date:  2014-10-16       Impact factor: 3.405
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