Literature DB >> 20436976

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

Anthony Bugaut1, Raphaël Rodriguez, Sunita Kumari, Shang-Te Danny Hsu, Shankar Balasubramanian.   

Abstract

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.

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Year:  2010        PMID： 20436976      PMCID： PMC3074098          DOI： 10.1039/c002418j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  31 in total

Review 1.  The role of the 5' untranslated region of an mRNA in translation regulation during development.

Authors:  A W van der Velden; A A Thomas
Journal:  Int J Biochem Cell Biol       Date:  1999-01       Impact factor: 5.085

Review 2.  RNA interference: listening to the sound of silence.

Authors:  P D Zamore
Journal:  Nat Struct Biol       Date:  2001-09

3.  G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

Authors:  James A Schouten; Sylvain Ladame; Stephen J Mason; Matthew A Cooper; Shankar Balasubramanian
Journal:  J Am Chem Soc       Date:  2003-05-14       Impact factor: 15.419

Review 4.  Progress in antisense technology.

Authors:  Stanley T Crooke
Journal:  Annu Rev Med       Date:  2004       Impact factor: 13.739

5.  Control of mammalian translation by mRNA structure near caps.

Authors:  Jeremy R Babendure; Jennie L Babendure; Jian-Hua Ding; Roger Y Tsien
Journal:  RNA       Date:  2006-03-15       Impact factor: 4.942

6.  Controlling gene expression in living cells through small molecule-RNA interactions.

Authors:  G Werstuck; M R Green
Journal:  Science       Date:  1998-10-09       Impact factor: 47.728

7.  Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

Authors:  M Kozak
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

8.  Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.

Authors:  Anh Tuân Phan; Vitaly Kuryavyi; Hai Yan Gaw; Dinshaw J Patel
Journal:  Nat Chem Biol       Date:  2005-07-17       Impact factor: 15.040

9.  Repression of translation of human estrogen receptor alpha by G-quadruplex formation.

Authors:  Graham D Balkwill; Kamila Derecka; Thomas P Garner; Charlie Hodgman; Anthony P F Flint; Mark S Searle
Journal:  Biochemistry       Date:  2009-12-08       Impact factor: 3.162

10.  Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205
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  37 in total

1.  The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.

Authors:  Ramla Shahid; Anthony Bugaut; Shankar Balasubramanian
Journal:  Biochemistry       Date:  2010-09-28       Impact factor: 3.162

2.  An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.

Authors:  Elizabeth O'Day; Minh T N Le; Shunsuke Imai; Shen Mynn Tan; Rory Kirchner; Haribabu Arthanari; Oliver Hofmann; Gerhard Wagner; Judy Lieberman
Journal:  J Biol Chem       Date:  2015-06-04       Impact factor: 5.157

3.  Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.

Authors:  Jin H Song; Hyun-Jin Kang; Libia A Luevano; Vijay Gokhale; Kui Wu; Ritu Pandey; H-H Sherry Chow; Laurence H Hurley; Andrew S Kraft
Journal:  Cell Chem Biol       Date:  2019-05-30       Impact factor: 8.116

4.  Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation.

Authors:  Anne Cammas; Alexandre Dubrac; Benjamin Morel; Assala Lamaa; Christian Touriol; Marie-Paule Teulade-Fichou; Hervé Prats; Stefania Millevoi
Journal:  RNA Biol       Date:  2015       Impact factor: 4.652

5.  Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes.

Authors:  Helena Guiset Miserachs; Daniela Donghi; Richard Börner; Silke Johannsen; Roland K O Sigel
Journal:  J Biol Inorg Chem       Date:  2016-10-04       Impact factor: 3.358

6.  A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.

Authors:  Dennis Gomez; Aurore Guédin; Jean-Louis Mergny; Bernard Salles; Jean-François Riou; Marie-Paule Teulade-Fichou; Patrick Calsou
Journal:  Nucleic Acids Res       Date:  2010-06-22       Impact factor: 16.971

7.  RNA Helicase Associated with AU-rich Element (RHAU/DHX36) Interacts with the 3'-Tail of the Long Non-coding RNA BC200 (BCYRN1).

Authors:  Evan P Booy; Ewan K S McRae; Ryan Howard; Soumya R Deo; Emmanuel O Ariyo; Edis Dzananovic; Markus Meier; Jörg Stetefeld; Sean A McKenna
Journal:  J Biol Chem       Date:  2016-01-05       Impact factor: 5.157

8.  Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses.

Authors:  Po-Chun Jimmy Huang; Penk-Yeir Low; Iren Wang; Shang-Te Danny Hsu; Takashi Angata
Journal:  J Biol Chem       Date:  2018-10-30       Impact factor: 5.157

9.  Small-molecule-mediated G-quadruplex isolation from human cells.

Authors:  Sebastian Müller; Sunita Kumari; Raphaël Rodriguez; Shankar Balasubramanian
Journal:  Nat Chem       Date:  2010-10-10       Impact factor: 24.427

Review 10.  Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Authors:  Shankar Balasubramanian; Laurence H Hurley; Stephen Neidle
Journal:  Nat Rev Drug Discov       Date:  2011-04       Impact factor: 84.694
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