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Literature DB >> 12733873

G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

James A Schouten¹, Sylvain Ladame, Stephen J Mason, Matthew A Cooper, Shankar Balasubramanian.

Abstract

G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12733873 DOI： 10.1021/ja029356w

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

15 in total

1. Targeting human telomerase for cancer therapeutics.

Authors: Lionel Guittat; Patrizia Alberti; Dennis Gomez; Anne De Cian; Gaëlle Pennarun; Thibault Lemarteleur; Chafke Belmokhtar; Rajaa Paterski; Hamid Morjani; Chantal Trentesaux; Eliane Mandine; François Boussin; Patrick Mailliet; Laurent Lacroix; Jean-François Riou; Jean-Louis Mergny
Journal: Cytotechnology Date: 2004-06 Impact factor: 2.058

2. Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

Authors: Anthony Bugaut; Raphaël Rodriguez; Sunita Kumari; Shang-Te Danny Hsu; Shankar Balasubramanian
Journal: Org Biomol Chem Date: 2010-04-30 Impact factor: 3.876

3. Selective recognition of a DNA G-quadruplex by an engineered antibody.

Authors: Himesh Fernando; Raphaël Rodriguez; Shankar Balasubramanian
Journal: Biochemistry Date: 2008-08-15 Impact factor: 3.162

4. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

Authors: James E Redman; J M Granadino-Roldán; James A Schouten; Sylvain Ladame; Anthony P Reszka; Stephen Neidle; Shankar Balasubramanian
Journal: Org Biomol Chem Date: 2008-10-30 Impact factor: 3.876

5. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.

Authors: Mallesham Bejugam; Sven Sewitz; Pravin S Shirude; Raphaël Rodriguez; Ramla Shahid; Shankar Balasubramanian
Journal: J Am Chem Soc Date: 2007-10-05 Impact factor: 15.419

G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

1. Targeting human telomerase for cancer therapeutics.

2. Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

3. Selective recognition of a DNA G-quadruplex by an engineered antibody.

4. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

5. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.

6. Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

7. Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands.

8. Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes.

9. Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry.

10. Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes.