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Literature DB >> 11524674

RNA interference: listening to the sound of silence.

Abstract

The term RNA interference (RNAi) describes the use of double-stranded RNA to target specific mRNAs for degradation, thereby silencing their expression. RNAi is one manifestation of a broad class of RNA silencing phenomena that are found in plants, animals and fungi. The discovery of RNAi has changed our understanding of how cells guard their genomes, led to the development of new strategies for blocking gene function, and may yet yield RNA-based drugs to treat human disease.

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Year: 2001 PMID： 11524674 DOI： 10.1038/nsb0901-746

Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368

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Cited

104 in total

Review 1. Disentangling the MYC web.

Authors: David Levens
Journal: Proc Natl Acad Sci U S A Date: 2002-04-30 Impact factor: 11.205

Review 2. RNA silencing and the mobile silencing signal.

Authors: Sizolwenkosi Mlotshwa; Olivier Voinnet; M Florian Mette; Marjori Matzke; Herve Vaucheret; Shou Wei Ding; Gail Pruss; Vicki B Vance
Journal: Plant Cell Date: 2002 Impact factor: 11.277

3. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.

Authors: Guangchao Sui; Christina Soohoo; El Bachir Affar; Frédérique Gay; Yujiang Shi; William C Forrester; Yang Shi
Journal: Proc Natl Acad Sci U S A Date: 2002-04-16 Impact factor: 11.205

4. DNA molecule provides a computing machine with both data and fuel.

Authors: Yaakov Benenson; Rivka Adar; Tamar Paz-Elizur; Zvi Livneh; Ehud Shapiro
Journal: Proc Natl Acad Sci U S A Date: 2003-02-24 Impact factor: 11.205

5. Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.

Authors: David Khoo; Cesar Perez; Ian Mohr
Journal: J Virol Date: 2002-12 Impact factor: 5.103

6. Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.

Authors: Dwaine A Braasch; Yinghui Liu; David R Corey
Journal: Nucleic Acids Res Date: 2002-12-01 Impact factor: 16.971

RNA interference: listening to the sound of silence.

Review 1. Disentangling the MYC web.

Review 2. RNA silencing and the mobile silencing signal.

3. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.

4. DNA molecule provides a computing machine with both data and fuel.

5. Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.

6. Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.

7. A CDC45 homolog in Arabidopsis is essential for meiosis, as shown by RNA interference-induced gene silencing.

8. A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs.

9. Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing.

10. Gene silencing using micro-RNA designed hairpins.