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Literature DB >> 20434785

Single cell analysis: the new frontier in 'omics'.

Abstract

Cellular heterogeneity that arises from stochastic expression of genes, proteins and metabolites is a fundamental principle of cell biology, but single cell analysis has been beyond the capability of 'omics' technology. This is rapidly changing with the recent examples of single cell genomics, transcriptomics, proteomics and metabolomics. The rate of change is expected to accelerate owing to emerging technologies that range from micro/nanofluidics to microfabricated interfaces for mass spectrometry to third- and fourth-generation automated DNA sequencers. As described in this review, single cell analysis is the new frontier in omics, and single cell omics has the potential to transform systems biology through new discoveries derived from cellular heterogeneity.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2010 PMID： 20434785 PMCID： PMC2876223 DOI： 10.1016/j.tibtech.2010.03.002

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

64 in total

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3. Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices.

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4. Direct multiplexed measurement of gene expression with color-coded probe pairs.

Authors: Gary K Geiss; Roger E Bumgarner; Brian Birditt; Timothy Dahl; Naeem Dowidar; Dwayne L Dunaway; H Perry Fell; Sean Ferree; Renee D George; Tammy Grogan; Jeffrey J James; Malini Maysuria; Jeffrey D Mitton; Paola Oliveri; Jennifer L Osborn; Tao Peng; Amber L Ratcliffe; Philippa J Webster; Eric H Davidson; Leroy Hood; Krassen Dimitrov
Journal: Nat Biotechnol Date: 2008-02-17 Impact factor: 54.908

5. Continuous base identification for single-molecule nanopore DNA sequencing.

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7. Chemistry and biology in femtoliter and picoliter volume droplets.

Authors: Daniel T Chiu; Robert M Lorenz
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8. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays.

Authors: D Pinkel; R Segraves; D Sudar; S Clark; I Poole; D Kowbel; C Collins; W L Kuo; C Chen; Y Zhai; S H Dairkee; B M Ljung; J W Gray; D G Albertson
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Review 9. RNA-Seq: a revolutionary tool for transcriptomics.

Authors: Zhong Wang; Mark Gerstein; Michael Snyder
Journal: Nat Rev Genet Date: 2009-01 Impact factor: 53.242

10. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Authors: Yiping He; Jian Wu; Devin C Dressman; Christine Iacobuzio-Donahue; Sanford D Markowitz; Victor E Velculescu; Luis A Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Journal: Nature Date: 2010-03-03 Impact factor: 49.962

195 in total

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3. Grand challenge commentary: Exploiting single-cell variation for new antibiotics.

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4. Using a nanopore for single molecule detection and single cell transfection.

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Journal: Analyst Date: 2012-05-29 Impact factor: 4.616

Review 5. Approaches for targeted proteomics and its potential applications in neuroscience.

Authors: Sumit Sethi; Dipti Chourasia; Ishwar S Parhar
Journal: J Biosci Date: 2015-09 Impact factor: 1.826

6. Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow.

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Journal: Proc Natl Acad Sci U S A Date: 2015-12-09 Impact factor: 11.205

7. Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis.

Authors: Brandon W Heimer; Brooke E Tam; Hadley D Sikes
Journal: Protein Eng Des Sel Date: 2015-09-18 Impact factor: 1.650

8. Mass Spectrometry Measurement of Single Suspended Cells Using a Combined Cell Manipulation System and a Single-Probe Device.

Authors: Shawna J Standke; Devon H Colby; Ryan C Bensen; Anthony W G Burgett; Zhibo Yang
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9. A Fluorescence-Activated Single-Droplet Dispenser for High Accuracy Single-Droplet and Single-Cell Sorting and Dispensing.

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Journal: Anal Chem Date: 2019-05-09 Impact factor: 6.986

Review 10. A systems approach to infectious disease.

Authors: Manon Eckhardt; Judd F Hultquist; Robyn M Kaake; Ruth Hüttenhain; Nevan J Krogan
Journal: Nat Rev Genet Date: 2020-02-14 Impact factor: 53.242