Literature DB >> 21079594

Grand challenge commentary: Exploiting single-cell variation for new antibiotics.

Erick Strauss1.   

Abstract

Variations between single members of a bacterial population can lead to antibiotic resistance that is not gene based. The future of effective infectious disease management might depend on a better understanding of this phenomenon and the potential to manipulate both it and microbial population dynamics in general.

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Year:  2010        PMID： 21079594     DOI： 10.1038/nchembio.483

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  19 in total

1.  Bacterial persistence as a phenotypic switch.

Authors:  Nathalie Q Balaban; Jack Merrin; Remy Chait; Lukasz Kowalik; Stanislas Leibler
Journal:  Science       Date:  2004-08-12       Impact factor: 47.728

Review 2.  Where will new antibiotics come from?

Authors:  Christopher Walsh
Journal:  Nat Rev Microbiol       Date:  2003-10       Impact factor: 60.633

Review 3.  Measurement of single-cell dynamics.

Authors:  David G Spiller; Christopher D Wood; David A Rand; Michael R H White
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

Review 4.  Microbial cell individuality and the underlying sources of heterogeneity.

Authors:  Simon V Avery
Journal:  Nat Rev Microbiol       Date:  2006-08       Impact factor: 60.633

Review 5.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

Review 6.  Phenotypic variation in bacteria: the role of feedback regulation.

Authors:  Wiep Klaas Smits; Oscar P Kuipers; Jan-Willem Veening
Journal:  Nat Rev Microbiol       Date:  2006-04       Impact factor: 60.633

Review 7.  Nature, nurture, or chance: stochastic gene expression and its consequences.

Authors:  Arjun Raj; Alexander van Oudenaarden
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582

Review 8.  Antibiotics for emerging pathogens.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

Review 9.  Single-molecule approaches to stochastic gene expression.

Authors:  Arjun Raj; Alexander van Oudenaarden
Journal:  Annu Rev Biophys       Date:  2009       Impact factor: 12.981

Review 10.  Tuberculosis: a problem with persistence.

Authors:  Graham R Stewart; Brian D Robertson; Douglas B Young
Journal:  Nat Rev Microbiol       Date:  2003-11       Impact factor: 60.633
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  1 in total

1.  Microbial metabolic exchange--the chemotype-to-phenotype link.

Authors:  Vanessa V Phelan; Wei-Ting Liu; Kit Pogliano; Pieter C Dorrestein
Journal:  Nat Chem Biol       Date:  2011-12-15       Impact factor: 15.040
  1 in total

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