Dual frequency resonator for 1.2 GHz EPR/16.2 MHz NMR co-imaging.

The development of a dual frequency resonator that enables both EPR and proton NMR imaging within the same resonator, magnet and gradient system is described. A novel design allows the same resonator to perform both EPR and proton NMR operation without moving resonator cables or switches. The resonator is capable of working at frequencies of 16.18 MHz for proton NMR and 1.2 GHz for EPR and is optimized for isolated rat heart experiments, measuring 22 mm in inner diameter and 19 mm in length. In EPR mode, the resonator functions as a one-loop-two gap resonator, electrically coupled through a half wavelength inverter. In NMR mode, it functions a single turn coil. Using the same loop for both modalities maximizes filling factor at both frequencies. Placing the tuning and switching controls away from the resonator prevents any inadvertent movement that would cause errors of EPR and NMR co-imaging registration. The resonator enabled good quality EPR and proton MRI of isolated rat hearts with precise registration. Copyright (c) 2010 Elsevier Inc. All rights reserved.