AIM: To investigate the prognostic impact of metastatic lymph node ratio (rN) on gastric cancer after curative distal gastrectomy. METHODS: A total of 634 gastric cancer patients who underwent curative resection (R0) of lymph nodes at distal gastrectomy in 1995-2004. Correlations between positive nodes and retrieved nodes, between rN and retrieved nodes, and between rN and negative lymph node (LN) count were analyzed respectively. Prognostic factors were identified by univariate and multivariate analyses. Staging accuracy of the pN category (5th UICC/TNM system) and the rN category was compared according to the survival rates of patients. A linear regression model was used to identify the relation between rN and 5-year survival rate of the patients. RESULTS: The number of dissected LNs was related with metastatic LNs but not related with rN. Cox regression analysis showed that depth of invasion, pN and rN category were the independent predictors of survival (P < 0.05). There was a significant difference in survival between LN stages classified by the rN category or by the pN category (P < 0.05). However, no significant difference was found in survival rate between LN stages classified by the pN category or by the rN category (P > 0.05). Linear regression model showed a significant linear correlation between rN and the 5-year survival rate of gastric cancer patients (beta = 0.862, P < 0.001). Pearson's correlation test revealed that negative LN count was negatively correlated with rN (P < 0.001). CONCLUSION: rN category is a better prognostic tool than the 5th UICC pN category for gastric cancer patients after curative distal gastrectomy. Increased negative LN count can reduce rN and improve the survival rate of gastric cancer patients.
AIM: To investigate the prognostic impact of metastatic lymph node ratio (rN) on gastric cancer after curative distal gastrectomy. METHODS: A total of 634 gastric cancerpatients who underwent curative resection (R0) of lymph nodes at distal gastrectomy in 1995-2004. Correlations between positive nodes and retrieved nodes, between rN and retrieved nodes, and between rN and negative lymph node (LN) count were analyzed respectively. Prognostic factors were identified by univariate and multivariate analyses. Staging accuracy of the pN category (5th UICC/TNM system) and the rN category was compared according to the survival rates of patients. A linear regression model was used to identify the relation between rN and 5-year survival rate of the patients. RESULTS: The number of dissected LNs was related with metastatic LNs but not related with rN. Cox regression analysis showed that depth of invasion, pN and rN category were the independent predictors of survival (P < 0.05). There was a significant difference in survival between LN stages classified by the rN category or by the pN category (P < 0.05). However, no significant difference was found in survival rate between LN stages classified by the pN category or by the rN category (P > 0.05). Linear regression model showed a significant linear correlation between rN and the 5-year survival rate of gastric cancerpatients (beta = 0.862, P < 0.001). Pearson's correlation test revealed that negative LN count was negatively correlated with rN (P < 0.001). CONCLUSION: rN category is a better prognostic tool than the 5th UICC pN category for gastric cancerpatients after curative distal gastrectomy. Increased negative LN count can reduce rN and improve the survival rate of gastric cancerpatients.
Authors: Y Kodera; Y Yamamura; Y Shimizu; A Torii; T Hirai; K Yasui; T Morimoto; T Kato; T Kito Journal: J Am Coll Surg Date: 1998-12 Impact factor: 6.113
Authors: Giovanni De Manzoni; Giuseppe Verlato; Franco Roviello; Alberto Di Leo; Daniele Marrelli; Paolo Morgagni; Felice Pasini; Luca Saragoni; Anna Tomezzoli Journal: Gastric Cancer Date: 2003 Impact factor: 7.370
Authors: Marianne Huebner; Michael Kendrick; Kaye M Reid-Lombardo; Florencia Que; Terry Therneau; Rui Qin; John Donohue; David Nagorney; Michael Farnell; Michael Sarr Journal: J Gastrointest Surg Date: 2012-03-16 Impact factor: 3.452
Authors: Ibrahim Sakcak; Barış Doğu Yıldız; Fatih Mehmet Avşar; Saadet Akturan; Kemal Kilic; Erdal Cosgun; Enver O Hamamci Journal: World J Gastroenterol Date: 2011-09-21 Impact factor: 5.742
Authors: Johan L Dikken; Cornelis J H van de Velde; Mithat Gönen; Marcel Verheij; Murray F Brennan; Daniel G Coit Journal: Ann Surg Oncol Date: 2012-05-23 Impact factor: 5.344
Authors: Ali Chehrei; Sakineh Amoueian; Jamshid Ansari; Mehdi Montazer; Mohammad Hossein Sanei Journal: J Res Med Sci Date: 2013-10 Impact factor: 1.852