OBJECTIVES: This trial assessed diagnostic accuracy of contrast-enhanced magnetic resonance angiography (MRA) with meglumine gadoterate (Gd-DOTA) at 3 Tesla (T) over unenhanced MRA at 3 T in non-coronary arterial diseases by comparing their accuracy with that of the gold standard, x-ray angiography. METHODS: Ninety-two patients with suspected non-coronary arterial disease underwent in fixed sequence unenhanced time-of flight (TOF) MRA, contrast-enhanced MRA using a Gd-DOTA bolus (intravenous bolus 0.1 mmol/kg) and x-ray angiography. RESULTS: Eighty-four patients (71 male, 13 female; median age 64.5 years) were included in an intent-to-treat efficacy analysis. Targeted vascular areas were aorto-iliac, calf, carotid, femoral, popliteal and renal. Within-patient accuracy was significantly higher with contrast-enhanced MRA using Gd-DOTA than with unenhanced MRA (p = 0.0003). There was 84.4 +/- 17.5% agreement between contrast-enhanced MRA (Gd-DOTA) and x-ray angiography, compared with 76.8 +/- 20.4% between non-enhanced MRA and x-ray angiography. Sensitivity and specificity were also better with Gd-DOTA compared with non-enhanced MRA at the segment level. Duration of the MRA procedure was 3.5 times shorter with Gd-DOTA compared with non-enhanced MRA. Six patients reported six mild or moderate adverse events. No serious adverse events occurred. CONCLUSIONS: Contrast-enhanced MRA using Gd-DOTA at 3 T was superior to unenhanced TOF MRA in the vascular territories investigated.
OBJECTIVES: This trial assessed diagnostic accuracy of contrast-enhanced magnetic resonance angiography (MRA) with meglumine gadoterate (Gd-DOTA) at 3 Tesla (T) over unenhanced MRA at 3 T in non-coronary arterial diseases by comparing their accuracy with that of the gold standard, x-ray angiography. METHODS: Ninety-two patients with suspected non-coronary arterial disease underwent in fixed sequence unenhanced time-of flight (TOF) MRA, contrast-enhanced MRA using a Gd-DOTA bolus (intravenous bolus 0.1 mmol/kg) and x-ray angiography. RESULTS: Eighty-four patients (71 male, 13 female; median age 64.5 years) were included in an intent-to-treat efficacy analysis. Targeted vascular areas were aorto-iliac, calf, carotid, femoral, popliteal and renal. Within-patient accuracy was significantly higher with contrast-enhanced MRA using Gd-DOTA than with unenhanced MRA (p = 0.0003). There was 84.4 +/- 17.5% agreement between contrast-enhanced MRA (Gd-DOTA) and x-ray angiography, compared with 76.8 +/- 20.4% between non-enhanced MRA and x-ray angiography. Sensitivity and specificity were also better with Gd-DOTA compared with non-enhanced MRA at the segment level. Duration of the MRA procedure was 3.5 times shorter with Gd-DOTA compared with non-enhanced MRA. Six patients reported six mild or moderate adverse events. No serious adverse events occurred. CONCLUSIONS: Contrast-enhanced MRA using Gd-DOTA at 3 T was superior to unenhanced TOF MRA in the vascular territories investigated.
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Authors: Bernd Tombach; Klaus Bohndorf; Wolfgang Brodtrager; Claus D Claussen; Christoph Düber; Michael Galanski; Eckhardt Grabbe; Giacomo Gortenuti; Michael Kuhn; Walter Gross-Fengels; Renate Hammerstingl; Brigitte Happel; Gertraud Heinz-Peer; Gregor Jung; Thomas Kittner; Roberto Lagalla; Philipp Lengsfeld; Reinhard Loose; Raymond H G Oyen; Pietro Pavlica; Christiane Pering; Roberto Pozzi-Mucelli; Thorsten Persigehl; Peter Reimer; Nomdo S Renken; Götz M Richter; Ernst J Rummeny; Fritz Schäfer; Malgorzata Szczerbo-Trojanowska; Andrzej Urbanik; Thomas J Vogl; Paul Hajek Journal: Eur Radiol Date: 2008-07-08 Impact factor: 5.315
Authors: Harald Kramer; Val M Runge; John N Morelli; Kenneth D Williams; L Gill Naul; Konstantin Nikolaou; Maximilian F Reiser; Bernd J Wintersperger Journal: Eur Radiol Date: 2011-04-09 Impact factor: 5.315