Literature DB >> 204006

Conformation of [Leu5]enkephalin from X-ray diffraction: features important for recognition at opiate receptor.

D Smith, J F Griffin.   

Abstract

The conformation of [Leu5]enkephalin is produced by a Tyr-Gly-Gly-Phe beta bend stabilized by antiparallel hydrogen bonding between tyrosine and phenylalanine. On the basis of a comparison of the observed structure with the structure of known opiate agonists, three hydrophilic and two hydrophobic regions have been identified as contributing to the recognition of the molecule at the opiate receptor site.

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Year:  1978        PMID： 204006     DOI： 10.1126/science.204006

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  Long time dynamics of Met-enkephalin: comparison of explicit and implicit solvent models.

Authors:  Min-yi Shen My; Karl F Freed
Journal:  Biophys J       Date:  2002-04       Impact factor: 4.033

2.  Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor.

Authors:  Arnaud Proteau-Gagné; Véronique Bournival; Kristina Rochon; Yves L Dory; Louis Gendron
Journal:  ACS Chem Neurosci       Date:  2010-09-17       Impact factor: 4.418

3.  The role of an L-leucine residue on the conformations of glycyl-L-leucine oligomers and its N- or C-terminal dependence: infrared absorption and Raman scattering studies.

Authors:  Hiro-Fumi Okabayashi; Hide-Hiro Kanbe; Charmian J O'Connor
Journal:  Eur Biophys J       Date:  2015-09-18       Impact factor: 1.733

4.  The role of crystallography in drug design.

Authors:  Jeffrey R Deschamps
Journal:  AAPS J       Date:  2005-12-07       Impact factor: 4.009

5.  Conformational stability and three-dimensional model of the delta-opioid pharmacophore for the extended antiparallel dimer structure of Met-enkephalin in water.

Authors:  Yng-Ching Wu; Jin-Yuan Hsieh; Hong-Chang Lin; Chi-Chuan Hwang
Journal:  J Mol Model       Date:  2006-09-14       Impact factor: 1.810

6.  A supermolecule study of the effect of hydration on the conformational behaviour of leucine-enkephalin.

Authors:  I N Demetropoulos; N Gresh
Journal:  J Comput Aided Mol Des       Date:  1991-04       Impact factor: 3.686

7.  Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides.

Authors:  Kristina Rochon; Arnaud Proteau-Gagné; Philippe Bourassa; Jean-François Nadon; Jérome Côté; Véronique Bournival; Fernand Gobeil; Brigitte Guérin; Yves L Dory; Louis Gendron
Journal:  ACS Chem Neurosci       Date:  2013-05-20       Impact factor: 4.418

8.  Ion mobility spectrometry: A personal view of its development at UCSB.

Authors:  Michael T Bowers
Journal:  Int J Mass Spectrom       Date:  2014-09-15       Impact factor: 1.986

9.  The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.

Authors:  Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
Journal:  J Med Chem       Date:  2008-09-27       Impact factor: 7.446

10.  In vitro steroidogenic properties of FK 33 824, a stable analog of methionine-enkephalin. Opiate-dopamine interaction in the control of aldosterone production.

Authors:  M Bevilacqua; T Vago; U Raggi; D Scorza; M Proverbio; E Malacco; G Norbiato
Journal:  J Endocrinol Invest       Date:  1982 Sep-Oct       Impact factor: 4.256
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