UNLABELLED: Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using (99m)Tc-DTPA or Technegas, an ultrafine dispersion of (99m)Tc-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with (99m)Tc-diethylenetriaminepentaacetate (DTPA) and Technegas. METHODS:Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both (99m)Tc-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. RESULTS: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in (99m)Tc-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with (99m)Tc-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. CONCLUSION: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease.
RCT Entities:
UNLABELLED: Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using (99m)Tc-DTPA or Technegas, an ultrafine dispersion of (99m)Tc-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with (99m)Tc-diethylenetriaminepentaacetate (DTPA) and Technegas. METHODS: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both (99m)Tc-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. RESULTS: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in (99m)Tc-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with (99m)Tc-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. CONCLUSION: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease.
Authors: Taoran Cui; G Wilson Miller; John P Mugler; Gordon D Cates; Jaime F Mata; Eduard E de Lange; Qijie Huang; Talissa A Altes; Fang-Fang Yin; Jing Cai Journal: Med Phys Date: 2018-10-23 Impact factor: 4.071
Authors: Jason Callahan; Michael S Hofman; Shankar Siva; Tomas Kron; Michal E Schneider; David Binns; Peter Eu; Rodney J Hicks Journal: Eur J Nucl Med Mol Imaging Date: 2013-11-06 Impact factor: 9.236
Authors: Douglas A Hoover; Dante Pi Capaldi; Khadija Sheikh; David A Palma; George B Rodrigues; A Rashid Dar; Edward Yu; Brian Dingle; Mark Landis; Walter Kocha; Michael Sanatani; Mark Vincent; Jawaid Younus; Sara Kuruvilla; Stewart Gaede; Grace Parraga; Brian P Yaremko Journal: BMC Cancer Date: 2014-12-11 Impact factor: 4.430