Literature DB >> 25478198

Advanced imaging in COPD: insights into pulmonary pathophysiology.

Stephen Milne1, Gregory G King1.   

Abstract

Chronic obstructive pulmonary disease (COPD) involves a complex interaction of structural and functional abnormalities. The two have long been studied in isolation. However, advanced imaging techniques allow us to simultaneously assess pathological processes and their physiological consequences. This review gives a comprehensive account of the various advanced imaging modalities used to study COPD, including computed tomography (CT), magnetic resonance imaging (MRI), and the nuclear medicine techniques positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Some more recent developments in imaging technology, including micro-CT, synchrotron imaging, optical coherence tomography (OCT) and electrical impedance tomography (EIT), are also described. The authors identify the pathophysiological insights gained from these techniques, and speculate on the future role of advanced imaging in both clinical and research settings.

Entities:  

Keywords:  Chronic obstructive pulmonary disease (COPD); medical imaging; pulmonary ventilation; respiratory function tests; respiratory physiology

Year:  2014        PMID： 25478198      PMCID： PMC4255158          DOI： 10.3978/j.issn.2072-1439.2014.11.30

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  115 in total

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4.  Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema.

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7.  Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.

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8.  Quantification of regional ventilation-perfusion ratios with PET.

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Journal:  Thorax       Date:  1992-11       Impact factor: 9.139

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Journal:  Chest       Date:  1994-11       Impact factor: 9.410
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  14 in total

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Review 4.  Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes.

Authors:  Eric A Hoffman; David A Lynch; R Graham Barr; Edwin J R van Beek; Grace Parraga
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Review 5.  Magnetic Nanoparticles in Cancer Therapy and Diagnosis.

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Review 6.  Pulmonary Functional Imaging: Part 2-State-of-the-Art Clinical Applications and Opportunities for Improved Patient Care.

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7.  Evaluation of pulmonary function using single-breath-hold dual-energy computed tomography with xenon: Results of a preliminary study.

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Review 8.  The Role of Computed Tomography for the Evaluation of Lung Disease in Alpha-1 Antitrypsin Deficiency.

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9.  Structural-functional lung imaging using a combined CT-EIT and a Discrete Cosine Transformation reconstruction method.

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10.  Assessing the Relationship between Lung Density and Function with Oxygen-Enhanced Magnetic Resonance Imaging in a Mouse Model of Emphysema.

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