Frédérique Blanc-Béguin1, Philippe Eliès2, Philippe Robin3, Raphaël Tripier4, Nelly Kervarec2, Catherine A Lemarié5, Simon Hennebicq3, Cécile Tromeur6, Virginie Cogulet7, Pierre-Yves Salaün3, Pierre-Yves Le Roux8. 1. Médecine Nucléaire, CHRU Brest, EA3878 (GETBO) IFR 148, Univ Brest, Avenue Foch, 29609, Brest Cedex, France. frederique.blanc@chu-brest.fr. 2. Service Général des plateformes, Plateforme d'Imagerie et de Mesures en Microscopie, Université de Brest, Université Bretagne Loire, Avenue Le Gorgeu, 29200, Brest, France. 3. Médecine Nucléaire, CHRU Brest, EA3878 (GETBO) IFR 148, Univ Brest, Avenue Foch, 29609, Brest Cedex, France. 4. Univ Brest UMR-CNRS 6521 (CEMCA), IFR 148, Avenue Le Gorgeu, 29200, Brest, France. 5. Univ Brest, EA3878 (GETBO), INSERM 1078, Avenue Camille Desmoulins, 29200, Brest, France. 6. Pneumologie, CHRU Brest, EA3878 (GETBO) IFR 148, Boulevard Tanguy Prigent, 29609, Brest Cedex, France. 7. Pharmacie, CHRU Brest, Avenue Foch, 29609, Brest Cedex, France. 8. Médecine Nucléaire, CHRU Brest, EA3878 (GETBO) IFR 148, Univ Brest, Avenue Foch, 29609, Brest Cedex, France. pierre-yves.leroux@chu-brest.fr.
Abstract
PURPOSE: The use of 68Ga-labelled carbon nanoparticles has been proposed for lung ventilation PET/CT imaging. However, no study has assessed the physical properties of 68Ga-labelled carbon nanoparticles. The aim of this study therefore was to evaluate the shape and size of 68Ga-labelled carbon nanoparticles, and to determine the composition of the aerosol, as opposed to 99mTc-labelled carbon nanoparticles aerosol. PROCEDURES: 99mTc- and 68Ga-labelled carbon nanoparticles, stable gallium carbon nanoparticles, 0.9 % NaCl and 0.1 N HCl-based carbon nanoparticles were produced using an unmodified Technegas® generator, following the usual technique used for clinical Technegas® production. The shape and size of particles were studied by transmission electron microscopy (TEM) after decay of the radioactive samples. The composition of the 68Zn- and 99Tc-labelled carbon nanoparticles aerosols was assessed using scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) analysis after decay of the 68Ga- and 99mTc-labelled carbon nanoparticles, respectively. RESULTS: On TEM, all samples showed similar shape with hexagonally structured primary particles, agglomerated in clusters. The mean diameters of primary stable gallium carbon nanoparticles, 99Tc- and 68Zn-labelled carbon nanoparticles were 22.4 ± 10 nm, 20.9 ± 7.2 nm and 19.8 ± 11.7 nm, respectively. CONCLUSION: Using Technegas® generator in the usual clinical way, 99mTc- and 68Ga-labelled carbon nanoparticles demonstrated similar shape and diameters in the same size range size. These results support the use of 68Ga-labelled carbon nanoparticles for the assessment of regional lung ventilation function with PET imaging.
PURPOSE: The use of 68Ga-labelled carbon nanoparticles has been proposed for lung ventilation PET/CT imaging. However, no study has assessed the physical properties of 68Ga-labelled carbon nanoparticles. The aim of this study therefore was to evaluate the shape and size of 68Ga-labelled carbon nanoparticles, and to determine the composition of the aerosol, as opposed to 99mTc-labelled carbon nanoparticles aerosol. PROCEDURES: 99mTc- and 68Ga-labelled carbon nanoparticles, stable galliumcarbon nanoparticles, 0.9 % NaCl and 0.1 N HCl-based carbon nanoparticles were produced using an unmodified Technegas® generator, following the usual technique used for clinical Technegas® production. The shape and size of particles were studied by transmission electron microscopy (TEM) after decay of the radioactive samples. The composition of the 68Zn- and 99Tc-labelled carbon nanoparticles aerosols was assessed using scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) analysis after decay of the 68Ga- and 99mTc-labelled carbon nanoparticles, respectively. RESULTS: On TEM, all samples showed similar shape with hexagonally structured primary particles, agglomerated in clusters. The mean diameters of primary stable galliumcarbon nanoparticles, 99Tc- and 68Zn-labelled carbon nanoparticles were 22.4 ± 10 nm, 20.9 ± 7.2 nm and 19.8 ± 11.7 nm, respectively. CONCLUSION: Using Technegas® generator in the usual clinical way, 99mTc- and 68Ga-labelled carbon nanoparticles demonstrated similar shape and diameters in the same size range size. These results support the use of 68Ga-labelled carbon nanoparticles for the assessment of regional lung ventilation function with PET imaging.
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