Literature DB >> 20392849

The RING finger domain of Varicella-Zoster virus ORF61p has E3 ubiquitin ligase activity that is essential for efficient autoubiquitination and dispersion of Sp100-containing nuclear bodies.

Matthew S Walters1, Christos A Kyratsous, Saul J Silverstein.   

Abstract

Varicella zoster virus encodes an immediate-early (IE) protein termed ORF61p that is orthologous to the herpes simplex virus IE protein ICP0. Although these proteins share several functional properties, ORF61p does not fully substitute for ICP0. The greatest region of similarity between these proteins is a RING finger domain. We demonstrate that disruption of the ORF61p RING finger domain by amino acid substitution (Cys19Gly) alters ORF61p intranuclear distribution and abolishes ORF61p-mediated dispersion of Sp100-containing nuclear bodies. In addition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase activity and is required for autoubiquitination and regulation of protein stability.

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Year:  2010        PMID： 20392849      PMCID： PMC2903287          DOI： 10.1128/JVI.00335-10

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells.

Authors:  L Pereira; M H Wolff; M Fenwick; B Roizman
Journal:  Virology       Date:  1977-04       Impact factor: 3.616

2.  Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.

Authors:  Ryan Hagglund; Charles Van Sant; Pascal Lopez; Bernard Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

3.  Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

Authors:  M P Quinlan; D M Knipe
Journal:  Mol Cell Biol       Date:  1985-05       Impact factor: 4.272

4.  Herpes simplex virus ICP0 mutants are hypersensitive to interferon.

Authors:  K L Mossman; H A Saffran; J R Smiley
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Characterization of the IE110 gene of herpes simplex virus type 1.

Authors:  L J Perry; F J Rixon; R D Everett; M C Frame; D J McGeoch
Journal:  J Gen Virol       Date:  1986-11       Impact factor: 3.891

7.  Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

Authors:  I H Gelman; S Silverstein
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

8.  Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression.

Authors:  J Chen; S Silverstein
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

9.  Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins.

Authors:  Roger D Everett; Chris Boutell; Carol McNair; Louise Grant; Anne Orr
Journal:  J Virol       Date:  2010-01-27       Impact factor: 5.103

10.  Activation of cellular promoters during herpes virus infection of biochemically transformed cells.

Authors:  R D Everett
Journal:  EMBO J       Date:  1985-08       Impact factor: 11.598
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  22 in total

1.  Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.

Authors:  Huifang Zhu; Chunfu Zheng; Junji Xing; Shuai Wang; Shuping Li; Rongtuan Lin; Karen L Mossman
Journal:  J Virol       Date:  2011-08-10       Impact factor: 5.103

2.  N-terminal phosphorylation sites of herpes simplex virus 1 ICP0 differentially regulate its activities and enhance viral replication.

Authors:  Heba H Mostafa; Thornton W Thompson; David J Davido
Journal:  J Virol       Date:  2012-12-05       Impact factor: 5.103

3.  Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.

Authors:  Stefan L Oliver; Edward Yang; Ann M Arvin
Journal:  J Virol       Date:  2016-12-16       Impact factor: 5.103

4.  ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic Envelopment in Differentiated Neuronal Cells.

Authors:  Hai-Fei Jiang; Wei Wang; Xuan Jiang; Wen-Bo Zeng; Zhang-Zhou Shen; Yi-Ge Song; Hong Yang; Xi-Juan Liu; Xiao Dong; Jing Zhou; Jin-Yan Sun; Fei-Long Yu; Lin Guo; Tong Cheng; Simon Rayner; Fei Zhao; Hua Zhu; Min-Hua Luo
Journal:  J Virol       Date:  2017-05-26       Impact factor: 5.103

5.  Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput Screening Assay.

Authors:  Thibaut Deschamps; Hope Waisner; Christos Dogrammatzis; Anuradha Roy; Shibin Chacko; Chamani Perera; Thomas E Prisinzano; Maria Kalamvoki
Journal:  J Virol       Date:  2019-06-14       Impact factor: 5.103

6.  The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.

Authors:  Travis Whitmer; Daniel Malouli; Luke S Uebelhoer; Victor R DeFilippis; Klaus Früh; Marieke C Verweij
Journal:  J Virol       Date:  2015-06-17       Impact factor: 5.103

7.  Varicella-zoster virus inhibition of the NF-κB pathway during infection of human dendritic cells: role for open reading frame 61 as a modulator of NF-κB activity.

Authors:  Elizabeth Sloan; Rodney Henriquez; Paul R Kinchington; Barry Slobedman; Allison Abendroth
Journal:  J Virol       Date:  2011-11-16       Impact factor: 5.103

8.  Attenuation of the adaptive immune response in rhesus macaques infected with simian varicella virus lacking open reading frame 61.

Authors:  Christine Meyer; Amelia Kerns; Kristen Haberthur; Jesse Dewane; Joshua Walker; Wayne Gray; Ilhem Messaoudi
Journal:  J Virol       Date:  2012-12-05       Impact factor: 5.103

Review 9.  Disruption of host antiviral resistances by gammaherpesvirus tegument proteins with homology to the FGARAT purine biosynthesis enzyme.

Authors:  Kevin Tsai; Troy E Messick; Paul M Lieberman
Journal:  Curr Opin Virol       Date:  2015-08-07       Impact factor: 7.090

10.  Identification of a hydrophobic domain in varicella-zoster virus ORF61 necessary for ORF61 self-interaction, viral replication, and skin pathogenesis.

Authors:  Li Wang; Jaya Rajamani; Marvin Sommer; Leigh Zerboni; Ann M Arvin
Journal:  J Virol       Date:  2013-01-23       Impact factor: 5.103
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