Literature DB >> 23345513

Identification of a hydrophobic domain in varicella-zoster virus ORF61 necessary for ORF61 self-interaction, viral replication, and skin pathogenesis.

Li Wang1, Jaya Rajamani, Marvin Sommer, Leigh Zerboni, Ann M Arvin.   

Abstract

The varicella-zoster virus (VZV) ORF61 protein is necessary for normal replication in vitro and virulence in human skin xenografts in the severe combined immunodeficiency mouse model in vivo. These experiments identify a hydrophobic domain that mediates ORF61 self-interaction. While not needed to inhibit host cell defenses, disruption of this domain (residues 250 to 320) severely impairs VZV growth, transactivation of the immediate early 63 and glycoprotein E genes, and the pathogenesis of VZV skin infection in vivo.

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Year:  2013        PMID： 23345513      PMCID： PMC3624212          DOI： 10.1128/JVI.02963-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  13 in total

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Authors:  Takahiro Niizuma; Leigh Zerboni; Marvin H Sommer; Hideki Ito; Stewart Hinchliffe; Ann M Arvin
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

2.  The RING finger domain of Varicella-Zoster virus ORF61p has E3 ubiquitin ligase activity that is essential for efficient autoubiquitination and dispersion of Sp100-containing nuclear bodies.

Authors:  Matthew S Walters; Christos A Kyratsous; Saul J Silverstein
Journal:  J Virol       Date:  2010-04-14       Impact factor: 5.103

3.  Identification of a dimerization domain in the C-terminal segment of the IE110 transactivator protein from herpes simplex virus.

Authors:  D M Ciufo; M A Mullen; G S Hayward
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

4.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

5.  Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesis.

Authors:  Li Wang; Marvin Sommer; Jaya Rajamani; Ann M Arvin
Journal:  J Virol       Date:  2009-05-20       Impact factor: 5.103

6.  Varicella-zoster virus ORF61 deletion mutants replicate in cell culture, but a mutant with stop codons in ORF61 reverts to wild-type virus.

Authors:  J I Cohen; H Nguyen
Journal:  Virology       Date:  1998-07-05       Impact factor: 3.616

7.  Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins.

Authors:  Roger D Everett; Chris Boutell; Carol McNair; Louise Grant; Anne Orr
Journal:  J Virol       Date:  2010-01-27       Impact factor: 5.103

8.  The replication cycle of varicella-zoster virus: analysis of the kinetics of viral protein expression, genome synthesis, and virion assembly at the single-cell level.

Authors:  Mike Reichelt; Jennifer Brady; Ann M Arvin
Journal:  J Virol       Date:  2009-02-04       Impact factor: 5.103

9.  Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.

Authors:  Mike Reichelt; Li Wang; Marvin Sommer; John Perrino; Adel M Nour; Nandini Sen; Armin Baiker; Leigh Zerboni; Ann M Arvin
Journal:  PLoS Pathog       Date:  2011-02-03       Impact factor: 6.823

10.  ELM--the database of eukaryotic linear motifs.

Authors:  Holger Dinkel; Sushama Michael; Robert J Weatheritt; Norman E Davey; Kim Van Roey; Brigitte Altenberg; Grischa Toedt; Bora Uyar; Markus Seiler; Aidan Budd; Lisa Jödicke; Marcel A Dammert; Christian Schroeter; Maria Hammer; Tobias Schmidt; Peter Jehl; Caroline McGuigan; Magdalena Dymecka; Claudia Chica; Katja Luck; Allegra Via; Andrew Chatr-Aryamontri; Niall Haslam; Gleb Grebnev; Richard J Edwards; Michel O Steinmetz; Heike Meiselbach; Francesca Diella; Toby J Gibson
Journal:  Nucleic Acids Res       Date:  2011-11-21       Impact factor: 16.971
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  1 in total

1.  Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication.

Authors:  Mohamed I Khalil; Xibing Che; Phillip Sung; Marvin H Sommer; John Hay; Ann M Arvin
Journal:  Virology       Date:  2016-02-23       Impact factor: 3.616
  1 in total

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