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Literature DB >> 2991915

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

Abstract

A HeLa cell transient-expression assay system was used to determine if isolated immediate early (alpha) genes from herpes simplex virus (HSV) could transcriptionally activate (transactivate) the type 1 (HSV-1) thymidine kinase (TK) gene [an early (beta) gene]. Cells transfected with the TK gene alone transcribed very low levels of TK RNA. Cells cotransfected with plasmids bearing the sequences that encode the alpha-gene product infected cell protein 0 or 4 (ICP0 or ICP4) and the TK gene faithfully transcribed high levels of TK RNA. The plasmid containing the sequences encoding ICP0 was a more potent transactivator than the plasmid containing the sequences for ICP4.

Entities: Disease Gene

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Year: 1985 PMID： 2991915 PMCID： PMC390548 DOI： 10.1073/pnas.82.16.5265

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

43 in total

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Journal: Virology Date: 1978-12 Impact factor: 3.616

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Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1977-06 Impact factor: 11.205

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Authors: R W Honess; B Roizman
Journal: J Virol Date: 1974-07 Impact factor: 5.103

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Journal: Biochem Biophys Res Commun Date: 1974-06-04 Impact factor: 3.575

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Journal: J Gen Virol Date: 1968-05 Impact factor: 3.891

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Journal: J Virol Date: 1983-08 Impact factor: 5.103

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Journal: J Virol Date: 1977-03 Impact factor: 5.103

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Authors: J M Leiden; R Buttyan; P G Spear
Journal: J Virol Date: 1976-11 Impact factor: 5.103

185 in total

1. Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.

Authors: W E Hobbs; N A DeLuca
Journal: J Virol Date: 1999-10 Impact factor: 5.103

2. Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways.

Authors: T M Soliman; S J Silverstein
Journal: J Virol Date: 2000-03 Impact factor: 5.103

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Authors: W E Hobbs; D E Brough; I Kovesdi; N A DeLuca
Journal: J Virol Date: 2001-04 Impact factor: 5.103

4. The initiator element in a herpes simplex virus type 1 late-gene promoter enhances activation by ICP4, resulting in abundant late-gene expression.

Authors: Dool-Bboon Kim; Susan Zabierowski; Neal A DeLuca
Journal: J Virol Date: 2002-02 Impact factor: 5.103

5. Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 renders expression of the immediate-early genes almost entirely dependent on ICP0.

Authors: K L Mossman; J R Smiley
Journal: J Virol Date: 1999-12 Impact factor: 5.103

6. The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.

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Journal: J Virol Date: 1989-11 Impact factor: 5.103

7. Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation.

Authors: Heba H Mostafa; Thornton W Thompson; Anna S Kushnir; Steve D Haenchen; Adam M Bayless; Joshua G Hilliard; Malen A Link; Lisa A Pitcher; Emma Loveday; Priscilla A Schaffer; David J Davido
Journal: J Virol Date: 2011-09-21 Impact factor: 5.103

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Authors: B Grondin; N DeLuca
Journal: J Virol Date: 2000-12 Impact factor: 5.103

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Journal: J Virol Date: 1989-11 Impact factor: 5.103

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Authors: C R Brown; M S Nakamura; J D Mosca; G S Hayward; S E Straus; L P Perera
Journal: J Virol Date: 1995-11 Impact factor: 5.103