Literature DB >> 26256000

Disruption of host antiviral resistances by gammaherpesvirus tegument proteins with homology to the FGARAT purine biosynthesis enzyme.

Kevin Tsai1, Troy E Messick2, Paul M Lieberman3.   

Abstract

All known gammaherpesviruses encode at least one conserved tegument protein that contains sequence homology to the cellular purine biosynthesis enzyme: phosphoribosylformylglycineamide amidotransferase (FGARAT, or PFAS). While no enzymatic activity have been found on these viral FGARAT-homology proteins (vFGARAT), they are important for disarming host intrinsic antiviral machinery. Most vFGARAT proteins disrupt the intrinsic antiviral response-associated cellular subnuclear structure: ProMyelocytic Leukemia (PML) associated nuclear body (PML-NB). vFGARATs from different viruses target different components of PML-NB to prevent cellular repression of viral infection. In addition, vFGARATs of rhadinoviruses were recently found to oligomerize with the cellular FGARAT to deamidate RIG-I and repress inflammatory cytokine production. In this review we discuss the diverse mechanisms of antiviral response disruption by gammaherpesvirus vFGARATs and the significance of the enzyme homology domain.
Copyright © 2015 Elsevier B.V. All rights reserved.

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Year:  2015        PMID： 26256000      PMCID： PMC4628856          DOI： 10.1016/j.coviro.2015.07.008

Source DB:  PubMed          Journal:  Curr Opin Virol        ISSN： 1879-6257            Impact factor:   7.090


  62 in total

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Authors:  C Lavau; A Marchio; M Fagioli; J Jansen; B Falini; P Lebon; F Grosveld; P P Pandolfi; P G Pelicci; A Dejean
Journal:  Oncogene       Date:  1995-09-07       Impact factor: 9.867

2.  The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0.

Authors:  G G Maul; R D Everett
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3.  Induction of the PML protein by interferons in normal and APL cells.

Authors:  M K Chelbi-Alix; L Pelicano; F Quignon; M H Koken; L Venturini; M Stadler; J Pavlovic; L Degos; H de Thé
Journal:  Leukemia       Date:  1995-12       Impact factor: 11.528

4.  The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1.

Authors:  F Korioth; G G Maul; B Plachter; T Stamminger; J Frey
Journal:  Exp Cell Res       Date:  1996-11-25       Impact factor: 3.905

5.  Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0).

Authors:  G G Maul; H H Guldner; J G Spivack
Journal:  J Gen Virol       Date:  1993-12       Impact factor: 3.891

6.  Primary structure of the herpesvirus saimiri genome.

Authors:  J C Albrecht; J Nicholas; D Biller; K R Cameron; B Biesinger; C Newman; S Wittmann; M A Craxton; H Coleman; B Fleckenstein
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

7.  Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.

Authors:  M Stadler; M K Chelbi-Alix; M H Koken; L Venturini; C Lee; A Saïb; F Quignon; L Pelicano; M C Guillemin; C Schindler
Journal:  Oncogene       Date:  1995-12-21       Impact factor: 9.867

8.  IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis.

Authors:  H H Guldner; C Szostecki; T Grötzinger; H Will
Journal:  J Immunol       Date:  1992-12-15       Impact factor: 5.422

9.  The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition.

Authors:  A M Ishov; G G Maul
Journal:  J Cell Biol       Date:  1996-08       Impact factor: 10.539

10.  Identification of a novel nuclear domain.

Authors:  C A Ascoli; G G Maul
Journal:  J Cell Biol       Date:  1991-03       Impact factor: 10.539
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Review 3.  Epigenetics and Genetics of Viral Latency.

Authors:  Paul M Lieberman
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6.  Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1.

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Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

Review 7.  Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System.

Authors:  Florian Full; Alexander S Hahn; Anna K Großkopf; Armin Ensser
Journal:  Viruses       Date:  2017-10-21       Impact factor: 5.048

8.  Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Authors:  Nick D Van Skike; Nana K Minkah; Chad H Hogan; Gary Wu; Peter T Benziger; Darby G Oldenburg; Mehmet Kara; Deborah M Kim-Holzapfel; Douglas W White; Scott A Tibbetts; Jarrod B French; Laurie T Krug
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9.  Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function.

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Review 10.  Epigenetic and epitranscriptomic regulation of viral replication.

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