Literature DB >> 20383294

ECHOGENIC LIPSOMES FOR TARGETED DRUG DELIVERY.

Christy K Holland1, David D McPherson.   

Abstract

Echogenic immunoliposomes (ELIP) are under development to enable ultrasound-controlled drug delivery. Mechanistic studies in vitro have revealed that stable cavitation is correlated with enhanced recombinant tissue Plasminogen Activator (rt-PA) thrombolysis, yet strategies to optimize the occurrence of such bubble activity and avoid potential harmful bioeffects have yet to be identified. Stable cavitation is characterized by bubbles pulsating gently in response to the time-varying acoustic pressure in an ultrasound field. A review of in vitro sonothrombolysis studies utilizing commercial US contrast agent or echogenic liposomes loaded with rt-PA to nucleate stable cavitation will be presented. Strategies for the development of ultrasound-enhanced thrombolysis and drug delivery will be discussed.

Entities:  

Year:  2009        PMID： 20383294      PMCID： PMC2851175     

Source DB:  PubMed          Journal:  Proc IEEE Int Symp Biomed Imaging        ISSN： 1945-7928


  19 in total

Review 1.  The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery.

Authors:  D R Groothuis
Journal:  Neuro Oncol       Date:  2000-01       Impact factor: 12.300

2.  Ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro porcine clot model.

Authors:  Christy K Holland; Sampada S Vaidya; Saurabh Datta; Constantin-C Coussios; George J Shaw
Journal:  Thromb Res       Date:  2007-09-14       Impact factor: 3.944

3.  In vitro studies of a new thrombus-specific ultrasound contrast agent.

Authors:  E C Unger; T P McCreery; R H Sweitzer; D Shen; G Wu
Journal:  Am J Cardiol       Date:  1998-06-18       Impact factor: 2.778

4.  Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication.

Authors:  J P Leonetti; P Machy; G Degols; B Lebleu; L Leserman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

Review 5.  Rationale for local drug delivery.

Authors:  D S Eccleston; M C Horrigan; S G Ellis
Journal:  Semin Interv Cardiol       Date:  1996-03

6.  A novel site-targeted ultrasonic contrast agent with broad biomedical application.

Authors:  G M Lanza; K D Wallace; M J Scott; W P Cacheris; D R Abendschein; D H Christy; A M Sharkey; J G Miller; P J Gaffney; S A Wickline
Journal:  Circulation       Date:  1996-12-15       Impact factor: 29.690

7.  Development of inherently echogenic liposomes as an ultrasonic contrast agent.

Authors:  H Alkan-Onyuksel; S M Demos; G M Lanza; M J Vonesh; M E Klegerman; B J Kane; J Kuszak; D D McPherson
Journal:  J Pharm Sci       Date:  1996-05       Impact factor: 3.534

8.  Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model.

Authors:  Jason M Meunier; Christy K Holland; Christopher J Lindsell; George J Shaw
Journal:  Ultrasound Med Biol       Date:  2007-04       Impact factor: 2.998

9.  Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes.

Authors:  George J Shaw; Jason M Meunier; Shao-Ling Huang; Christopher J Lindsell; David D McPherson; Christy K Holland
Journal:  Thromb Res       Date:  2009-02-13       Impact factor: 3.944

10.  Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent.

Authors:  Saurabh Datta; Constantin-C Coussios; Azzdine Y Ammi; T Douglas Mast; Gabrielle M de Courten-Myers; Christy K Holland
Journal:  Ultrasound Med Biol       Date:  2008-04-18       Impact factor: 2.998
View more
  7 in total

1.  Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.

Authors:  Natalya Rapoport; Kweon-Ho Nam; Roohi Gupta; Zhongao Gao; Praveena Mohan; Allison Payne; Nick Todd; Xin Liu; Taeho Kim; Jill Shea; Courtney Scaife; Dennis L Parker; Eun-Kee Jeong; Anne M Kennedy
Journal:  J Control Release       Date:  2011-01-26       Impact factor: 9.776

2.  Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.

Authors:  Jonathan A Kopechek; Kevin J Haworth; Jason L Raymond; T Douglas Mast; Stephen R Perrin; Melvin E Klegerman; Shaoling Huang; Tyrone M Porter; David D McPherson; Christy K Holland
Journal:  J Acoust Soc Am       Date:  2011-11       Impact factor: 1.840

Review 3.  Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer.

Authors:  Natalya Rapoport
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2012-06-22

Review 4.  Phase-shift, stimuli-responsive drug carriers for targeted delivery.

Authors:  Brian E O'Neill; Natalya Rapoport
Journal:  Ther Deliv       Date:  2011-09

Review 5.  Novel delivery approaches for cancer therapeutics.

Authors:  Ashim K Mitra; Vibhuti Agrahari; Abhirup Mandal; Kishore Cholkar; Chandramouli Natarajan; Sujay Shah; Mary Joseph; Hoang M Trinh; Ravi Vaishya; Xiaoyan Yang; Yi Hao; Varun Khurana; Dhananjay Pal
Journal:  J Control Release       Date:  2015-10-09       Impact factor: 9.776

Review 6.  Ultrasound biomicroscopy in small animal research: applications in molecular and preclinical imaging.

Authors:  A Greco; M Mancini; S Gargiulo; M Gramanzini; P P Claudio; A Brunetti; M Salvatore
Journal:  J Biomed Biotechnol       Date:  2011-10-25

7.  Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis.

Authors:  Feili Yan; Zhirong Zhong; Yao Wang; Yue Feng; Zhiqiang Mei; Hui Li; Xiang Chen; Liang Cai; Chunhong Li
Journal:  J Nanobiotechnology       Date:  2020-08-20       Impact factor: 10.435
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.