Literature DB >> 20364126

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.

Devaraj Subramanian1, Vibor Laketa, Rainer Müller, Christian Tischer, Sirus Zarbakhsh, Rainer Pepperkok, Carsten Schultz.   

Abstract

Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phospholipid residing on early endosomes, where it is proposed to be involved in endosomal fusion. We synthesized membrane-permeant derivatives of PtdIns(3)P, including a caged version that is to our knowledge the first photoactivatable phosphoinositide derivative developed so far. In living cells, photoactivation of caged PtdIns(3)P induced rapid endosomal fusion in an EEA1-dependent fashion, thus providing in vivo evidence that PtdIns(3)P is a sufficient signal for driving this process.

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Year:  2010        PMID： 20364126     DOI： 10.1038/nchembio.348

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  23 in total

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Journal:  J Biol Chem       Date:  1999-04-02       Impact factor: 5.157

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Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

Review 3.  Autophagosome formation: core machinery and adaptations.

Authors:  Zhiping Xie; Daniel J Klionsky
Journal:  Nat Cell Biol       Date:  2007-10       Impact factor: 28.824

4.  EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.

Authors:  A Simonsen; R Lippé; S Christoforidis; J M Gaullier; A Brech; J Callaghan; B H Toh; C Murphy; M Zerial; H Stenmark
Journal:  Nature       Date:  1998-07-30       Impact factor: 49.962

5.  Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression.

Authors:  W Li; J Llopis; M Whitney; G Zlokarnik; R Y Tsien
Journal:  Nature       Date:  1998-04-30       Impact factor: 49.962

6.  Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1.

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Journal:  J Biol Chem       Date:  2001-10-15       Impact factor: 5.157

7.  Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives.

Authors:  C Dinkel; M Moody; A Traynor-Kaplan; C Schultz
Journal:  Angew Chem Int Ed Engl       Date:  2001       Impact factor: 15.336

8.  Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth.

Authors:  Vibor Laketa; Sirus Zarbakhsh; Eva Morbier; Devaraj Subramanian; Carlo Dinkel; Justin Brumbaugh; Pascale Zimmermann; Rainer Pepperkok; Carsten Schultz
Journal:  Chem Biol       Date:  2009-11-25

Review 9.  Phosphoinositides in constitutive membrane traffic.

Authors:  Michael G Roth
Journal:  Physiol Rev       Date:  2004-07       Impact factor: 37.312

10.  Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest.

Authors:  R A Fratti; J M Backer; J Gruenberg; S Corvera; V Deretic
Journal:  J Cell Biol       Date:  2001-08-06       Impact factor: 10.539
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  24 in total

1.  Challenges in studying phospholipid signaling.

Authors:  Carsten Schultz
Journal:  Nat Chem Biol       Date:  2010-07       Impact factor: 15.040

Review 2.  Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems.

Authors:  Sohum Mehta; Jin Zhang
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

3.  Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

Authors:  York Posor; Marielle Eichhorn-Gruenig; Dmytro Puchkov; Johannes Schöneberg; Alexander Ullrich; André Lampe; Rainer Müller; Sirus Zarbakhsh; Federico Gulluni; Emilio Hirsch; Michael Krauss; Carsten Schultz; Jan Schmoranzer; Frank Noé; Volker Haucke
Journal:  Nature       Date:  2013-07-03       Impact factor: 49.962

4.  Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.

Authors:  Theofilos Papadopoulos; Hong Jun Rhee; Devaraj Subramanian; Foteini Paraskevopoulou; Rainer Mueller; Carsten Schultz; Nils Brose; Jeong-Seop Rhee; Heinrich Betz
Journal:  J Biol Chem       Date:  2016-12-09       Impact factor: 5.157

5.  Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Authors:  Alexander M Walter; Rainer Müller; Bassam Tawfik; Keimpe Db Wierda; Paulo S Pinheiro; André Nadler; Anthony W McCarthy; Iwona Ziomkiewicz; Martin Kruse; Gregor Reither; Jens Rettig; Martin Lehmann; Volker Haucke; Bertil Hille; Carsten Schultz; Jakob Balslev Sørensen
Journal:  Elife       Date:  2017-10-25       Impact factor: 8.140

6.  A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes.

Authors:  Weigang Huang; Xiaoyang Wang; Stuart Endo-Streeter; Matthew Barrett; Jarod Waybright; Christian Wohlfeld; Nicole Hajicek; T Kendall Harden; John Sondek; Qisheng Zhang
Journal:  J Biol Chem       Date:  2017-12-20       Impact factor: 5.157

Review 7.  Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

Authors:  Andrea L Marat; Volker Haucke
Journal:  EMBO J       Date:  2016-02-17       Impact factor: 11.598

8.  Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.

Authors:  Haibin Wang; Dinah Loerke; Caroline Bruns; Rainer Müller; Philipp-Alexander Koch; Dmytro Puchkov; Carsten Schultz; Volker Haucke
Journal:  J Biol Chem       Date:  2019-12-12       Impact factor: 5.157

9.  A phosphoinositide conversion mechanism for exit from endosomes.

Authors:  Katharina Ketel; Michael Krauss; Anne-Sophie Nicot; Dmytro Puchkov; Marnix Wieffer; Rainer Müller; Devaraj Subramanian; Carsten Schultz; Jocelyn Laporte; Volker Haucke
Journal:  Nature       Date:  2016-01-13       Impact factor: 49.962

Review 10.  The systematic analysis of protein-lipid interactions comes of age.

Authors:  Antoine-Emmanuel Saliba; Ivana Vonkova; Anne-Claude Gavin
Journal:  Nat Rev Mol Cell Biol       Date:  2015-10-28       Impact factor: 94.444
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