| Literature DB >> 12203630 |
C Dinkel1, M Moody, A Traynor-Kaplan, C Schultz.
Abstract
A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3 . Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis.Entities:
Keywords: cyclitols; cystic fibrosis; phosphoinositides; secretion; signal transduction
Year: 2001 PMID： 12203630 DOI： 10.1002/1521-3773(20010817)40:16<3004::AID-ANIE3004>3.0.CO;2-O
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336