Literature DB >> 20336235

Complexity and simplicity in the biosynthesis of enediyne natural products.

Zhao-Xun Liang1.   

Abstract

The review highlights the recent progress on the elucidation of the biosynthetic mechanism of enediyne natural products. A large body of knowledge has been gathered from the genetic, biochemical and structural studies since the sequencing of the first two enediyne gene clusters in 2002. Primary attention is devoted to the novel pathways and enzymes in the biosynthesis of the enediyne warhead as well as the peripheral moieties.

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Year:  2010        PMID： 20336235     DOI： 10.1039/b908165h

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  24 in total

1.  Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

Authors:  Jeffrey D Rudolf; Xiaohui Yan; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2015-08-29       Impact factor: 3.346

2.  Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.

Authors:  Xiaohui Yan; Jian-Jun Chen; Ajeeth Adhikari; Dong Yang; Ivana Crnovcic; Nan Wang; Chin-Yuan Chang; Christoph Rader; Ben Shen
Journal:  Org Lett       Date:  2017-10-31       Impact factor: 6.005

3.  Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.

Authors:  Xiaohui Yan; Jian-Jun Chen; Ajeeth Adhikari; Christiana N Teijaro; Huiming Ge; Ivana Crnovcic; Chin-Yuan Chang; Thibault Annaval; Dong Yang; Christoph Rader; Ben Shen
Journal:  Org Lett       Date:  2018-09-13       Impact factor: 6.005

4.  Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes.

Authors:  Amy L Lane; Sang-Jip Nam; Takashi Fukuda; Kazuya Yamanaka; Christopher A Kauffman; Paul R Jensen; William Fenical; Bradley S Moore
Journal:  J Am Chem Soc       Date:  2013-03-07       Impact factor: 15.419

Review 5.  Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.

Authors:  Christiana N Teijaro; Ajeeth Adhikari; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-13       Impact factor: 3.346

Review 6.  A sea of biosynthesis: marine natural products meet the molecular age.

Authors:  Amy L Lane; Bradley S Moore
Journal:  Nat Prod Rep       Date:  2010-12-17       Impact factor: 13.423

7.  Synthesis of the carboline disaccharide domain of shishijimicin A.

Authors:  K C Nicolaou; J L Kiappes; Weiwei Tian; Vijaya B Gondi; Jochen Becker
Journal:  Org Lett       Date:  2011-06-28       Impact factor: 6.005

8.  Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2013-09-17       Impact factor: 15.419

9.  Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-08       Impact factor: 15.336

10.  Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation.

Authors:  Wenli Li; Xiuling Li; Tingting Huang; Qihui Teng; Ivana Crnovcic; Christoph Rader; Ben Shen
Journal:  Bioorg Med Chem       Date:  2016-04-08       Impact factor: 3.641
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