Literature DB >> 29086572

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.

Xiaohui Yan1, Jian-Jun Chen1, Ajeeth Adhikari1, Dong Yang1, Ivana Crnovcic1, Nan Wang1, Chin-Yuan Chang1, Christoph Rader1, Ben Shen1.   

Abstract

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

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Year:  2017        PMID： 29086572      PMCID： PMC6204215          DOI： 10.1021/acs.orglett.7b03120

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  18 in total

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4.  Biochemical prophage induction assay: a rapid test for antitumor agents that interact with DNA.

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Journal:  Mol Carcinog       Date:  2013-07-16       Impact factor: 4.784

6.  Uncialamycin, a new enediyne antibiotic.

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Review 7.  Biosynthesis of enediyne antitumor antibiotics.

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Review 9.  Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

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  18 in total

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2.  Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.

Authors:  Xiaohui Yan; Jian-Jun Chen; Ajeeth Adhikari; Christiana N Teijaro; Huiming Ge; Ivana Crnovcic; Chin-Yuan Chang; Thibault Annaval; Dong Yang; Christoph Rader; Ben Shen
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6.  C-N-Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis.

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7.  Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577.

Authors:  Zilong Wang; Zhongqing Wen; Ling Liu; Xiangcheng Zhu; Ben Shen; Xiaohui Yan; Yanwen Duan; Yong Huang
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9.  Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.

Authors:  Ajeeth Adhikari; Christiana N Teijaro; Xiaohui Yan; Chin-Yuan Chang; Chun Gui; Yu-Chen Liu; Ivana Crnovcic; Dong Yang; Thibault Annaval; Christoph Rader; Ben Shen
Journal:  J Med Chem       Date:  2020-07-24       Impact factor: 7.446

10.  Resistance to Enediyne Antitumor Antibiotics by Sequestration.

Authors:  Chin-Yuan Chang; Xiaohui Yan; Ivana Crnovcic; Thibault Annaval; Changsoo Chang; Boguslaw Nocek; Jeffrey D Rudolf; Dong Yang; Gyorgy Babnigg; Andrzej Joachimiak; George N Phillips; Ben Shen
Journal:  Cell Chem Biol       Date:  2018-06-21       Impact factor: 8.116
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