Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The interface between transcription and mechanisms maintaining genome integrity.

Literature DB >> 20194025

The interface between transcription and mechanisms maintaining genome integrity.

Abstract

Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication. Copyright 2010 Elsevier Ltd. All rights reserved.

Mesh：

Substances：

Year: 2010 PMID： 20194025 DOI： 10.1016/j.tibs.2010.02.001

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

Keyword Cloud
Cited

38 in total

1. Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.

Authors: Giel Hendriks; Jacob G Jansen; Leon H F Mullenders; Niels de Wind
Journal: Transcription Date: 2010 Sep-Oct

The interface between transcription and mechanisms maintaining genome integrity.

1. Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.

2. NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair.

3. Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?

Review 4. The ubiquitin-proteasome system of Saccharomyces cerevisiae.

Review 5. Balancing eukaryotic replication asymmetry with replication fidelity.

6. Crucial role of a dicarboxylic motif in the catalytic center of yeast RNA polymerases.

7. BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.

Review 8. Regulation of active genome integrity and expression by Rad26p.

9. Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.

Review 10. The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.