Literature DB >> 20191319

The Gewald multicomponent reaction.

Yijun Huang1, Alexander Dömling.   

Abstract

The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products.

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Year:  2010        PMID： 20191319     DOI： 10.1007/s11030-010-9229-6

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


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