Literature DB >> 31754553

One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8 and Formamide.

Taoda Shi1, Lynn Kaneko1, Michael Sandino1, Ryan Busse1, Mae Zhang1, Damian Mason1, Jason Machulis1, Andrew J Ambrose1, Donna D Zhang1, Eli Chapman1.   

Abstract

Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that previously required a three step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S8 and formamide. The reported reaction is characterized by step economy, reduced catalyst loading and easy purification.

Entities:  

Keywords:  catalytic; green chemistry; multi-component reaction; thieno[2,3-d]pyrimidin-4(3H)-ones

Year:  2018        PMID： 31754553      PMCID： PMC6871654          DOI： 10.1021/acssuschemeng.8b05276

Source DB:  PubMed          Journal:  ACS Sustain Chem Eng        ISSN： 2168-0485            Impact factor:   8.198


  12 in total

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  3 in total

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  3 in total

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