| Literature DB >> 17451949 |
Gang Zhao1, Rajesh R Iyengar, Andrew S Judd, Barbara Cool, William Chiou, Lemma Kifle, Ernst Frevert, Hing Sham, Philip R Kym.
Abstract
AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen was performed in order to identify chemotypes that are bound by AMPK. A novel thienopyridone compound (1) was identified and subsequently optimized. The structure-activity relationships that emerged from this effort are described.Entities:
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Year: 2007 PMID： 17451949 DOI： 10.1016/j.bmcl.2007.04.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823