Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.

Literature DB >> 20190084

Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.

Han-Na Lee¹, Jianqiang Huang, Jong-Hyuk Im, Seon-Hye Kim, Jun-Hee Noh, Stanley N Cohen, Eung-Soo Kim.

Abstract

A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.

Entities: Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20190084 PMCID： PMC2863465 DOI： 10.1128/AEM.02426-09

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

17 in total

Review 1. Novel biologically active natural and unnatural products.

Authors: David C Myles
Journal: Curr Opin Biotechnol Date: 2003-12 Impact factor: 9.740

2. Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes.

Authors: J A Soliveri; J Gomez; W R Bishai; K F Chater
Journal: Microbiology Date: 2000-02 Impact factor: 2.777

Review 3. Regulation of secondary metabolism in streptomycetes.

Authors: Mervyn J Bibb
Journal: Curr Opin Microbiol Date: 2005-04 Impact factor: 7.934

Review 4. Plasticity of the streptomyces genome-evolution and engineering of new antibiotics.

Authors: Daslav Hranueli; John Cullum; Bojan Basrak; Pavle Goldstein; Paul F Long
Journal: Curr Med Chem Date: 2005 Impact factor: 4.530

5. The stringent response in Streptomyces coelicolor A3(2).

Authors: E Strauch; E Takano; H A Baylis; M J Bibb
Journal: Mol Microbiol Date: 1991-02 Impact factor: 3.501

Review 6. Multilevel regulation of Streptomyces differentiation.

Authors: K F Chater
Journal: Trends Genet Date: 1989-11 Impact factor: 11.639

7. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor.

Authors: Yong-Gu Ryu; Michael J Butler; Keith F Chater; Kye Joon Lee
Journal: Appl Environ Microbiol Date: 2006-09-01 Impact factor: 4.792

8. Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.

Authors: Amy M Lum; Jianqiang Huang; C Richard Hutchinson; Camilla M Kao
Journal: Metab Eng Date: 2004-07 Impact factor: 9.783

9. A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.

Authors: Chinping Chng; Amy M Lum; Jonathan A Vroom; Camilla M Kao
Journal: Proc Natl Acad Sci U S A Date: 2008-08-06 Impact factor: 11.205

10. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.

Authors: Bertolt Gust; Greg L Challis; Kay Fowler; Tobias Kieser; Keith F Chater
Journal: Proc Natl Acad Sci U S A Date: 2003-01-31 Impact factor: 11.205

15 in total

Review 1. The TetR family of regulators.

Authors: Leslie Cuthbertson; Justin R Nodwell
Journal: Microbiol Mol Biol Rev Date: 2013-09 Impact factor: 11.056

2. SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production.

Authors: Dana Ulanova; Shigeru Kitani; Eiichiro Fukusaki; Takuya Nihira
Journal: Appl Environ Microbiol Date: 2013-10-11 Impact factor: 4.792

3. Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor.

Authors: Seon-Hye Kim; Han-Na Lee; Hye-Jin Kim; Eung-Soo Kim
Journal: Appl Environ Microbiol Date: 2011-01-07 Impact factor: 4.792

4. Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator.

Authors: Delin Xu; Nicolas Seghezzi; Catherine Esnault; Marie-Joelle Virolle
Journal: Appl Environ Microbiol Date: 2010-10-08 Impact factor: 4.792

5. Minimal polyketide pathway expression in an actinorhodin cluster-deleted and regulation-stimulated Streptomyces coelicolor.

Authors: Han-Na Lee; Hye-Jin Kim; Pil Kim; Heung-Shick Lee; Eung-Soo Kim
Journal: J Ind Microbiol Biotechnol Date: 2012-01-18 Impact factor: 3.346

6. Identification of a cyclosporine-specific P450 hydroxylase gene through targeted cytochrome P450 complement (CYPome) disruption in Sebekia benihana.

Authors: Mi-Jin Lee; Hyun-Bum Kim; Yeo Joon Yoon; Kyuboem Han; Eung-Soo Kim
Journal: Appl Environ Microbiol Date: 2013-01-25 Impact factor: 4.792

7. Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor.

Authors: Han-Na Lee; Jin-Su Kim; Pil Kim; Heung-Shick Lee; Eung-Soo Kim
Journal: Appl Environ Microbiol Date: 2013-04-19 Impact factor: 4.792

8. GouR, a TetR family transcriptional regulator, coordinates the biosynthesis and export of gougerotin in Streptomyces graminearus.

Authors: Junhong Wei; Yuqing Tian; Guoqing Niu; Huarong Tan
Journal: Appl Environ Microbiol Date: 2013-11-15 Impact factor: 4.792

9. The -omics Era- Toward a Systems-Level Understanding of Streptomyces.

Authors: Zhan Zhou; Jianying Gu; Yi-Ling Du; Yong-Quan Li; Yufeng Wang
Journal: Curr Genomics Date: 2011-09 Impact factor: 2.236

10. Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy.

Authors: Ji-Hye Nah; Hye-Jin Kim; Han-Na Lee; Mi-Jin Lee; Si-Sun Choi; Eung-Soo Kim
Journal: Biomed Res Int Date: 2013-03-04 Impact factor: 3.411