Literature DB >> 14662393

Novel biologically active natural and unnatural products.

David C Myles1.   

Abstract

Natural products have been used as medicinal agents for many years. In addition, these compounds have served as the starting points for semisynthetic analogs with improved properties. This review highlights work on several classes of natural products and their derivatives, including both well established and emerging structural classes that are in, or nearing, clinical use for a variety of important indications.

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Year:  2003        PMID: 14662393     DOI: 10.1016/j.copbio.2003.10.013

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN: 0958-1669            Impact factor:   9.740


  4 in total

1.  Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation.

Authors:  Leandro Vetcher; Zong-Qiang Tian; Robert McDaniel; Andreas Rascher; W Peter Revill; C Richard Hutchinson; Zhihao Hu
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

2.  Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.

Authors:  Han-Na Lee; Jianqiang Huang; Jong-Hyuk Im; Seon-Hye Kim; Jun-Hee Noh; Stanley N Cohen; Eung-Soo Kim
Journal:  Appl Environ Microbiol       Date:  2010-02-26       Impact factor: 4.792

3.  Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.

Authors:  Shin-Hae Park; Si-Sun Choi; Yoon Jung Kim; Yong Keun Chang; David H Sherman; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2009-05-01       Impact factor: 3.346

4.  PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

Authors:  Meng S Choy; Mark Swingle; Brandon D'Arcy; Kevin Abney; Scott F Rusin; Arminja N Kettenbach; Rebecca Page; Richard E Honkanen; Wolfgang Peti
Journal:  J Am Chem Soc       Date:  2017-11-28       Impact factor: 15.419

  4 in total

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