Literature DB >> 21216912

Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor.

Seon-Hye Kim1, Han-Na Lee, Hye-Jin Kim, Eung-Soo Kim.   

Abstract

Through microarray analysis of an antibiotic-downregulator-deleted Streptomyces coelicolor ΔwblA ΔSCO1712 mutant, 28 wblA- and SCO1712-dependent genes were identified and characterized. Among 14 wblA- and SCO1712-independent genes, a carbon flux regulating 6-phosphofructokinase SCO5426 was additionally disrupted in the ΔwblA ΔSCO1712 mutant and further stimulated actinorhodin production in S. coelicolor, implying that both regulatory and precursor flux pathways could be synergistically optimized for antibiotic production.

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Year:  2011        PMID： 21216912      PMCID： PMC3067302          DOI： 10.1128/AEM.02346-10

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  21 in total

1.  Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein.

Authors:  P Arias; M A Fernández-Moreno; F Malpartida
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

Review 2.  Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete.

Authors:  D A Hopwood; K F Chater; M J Bibb
Journal:  Biotechnology       Date:  1995

Review 3.  1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2).

Authors:  Mervyn Bibb
Journal:  Microbiology (Reading)       Date:  1996-06       Impact factor: 2.777

4.  Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis.

Authors:  K S Vetrivel; K Dharmalingam
Journal:  J Genet       Date:  2001-04       Impact factor: 1.166

Review 5.  Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species.

Authors:  Gregory L Challis; David A Hopwood
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-11       Impact factor: 11.205

6.  Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.

Authors:  Amy M Lum; Jianqiang Huang; C Richard Hutchinson; Camilla M Kao
Journal:  Metab Eng       Date:  2004-07       Impact factor: 9.783

7.  Intergeneric conjugal transfer of plasmid DNA from Escherichia coli to Kitasatospora setae, a bafilomycin B1 producer.

Authors:  Sun-Uk Choi; Chang-Kwon Lee; Yong-Il Hwang; Hiroshi Kinoshita; Takuya Nihira
Journal:  Arch Microbiol       Date:  2004-02-07       Impact factor: 2.552

8.  Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains.

Authors:  Eduardo Rodriguez; Zhihao Hu; Sally Ou; Yanina Volchegursky; C Richard Hutchinson; Robert McDaniel
Journal:  J Ind Microbiol Biotechnol       Date:  2003-04-16       Impact factor: 3.346

9.  Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus.

Authors:  M J Bibb; G R Janssen; J M Ward
Journal:  Gene       Date:  1985       Impact factor: 3.688

10.  Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans.

Authors:  S Horinouchi; O Hara; T Beppu
Journal:  J Bacteriol       Date:  1983-09       Impact factor: 3.490
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  10 in total

Review 1.  The TetR family of regulators.

Authors:  Leslie Cuthbertson; Justin R Nodwell
Journal:  Microbiol Mol Biol Rev       Date:  2013-09       Impact factor: 11.056

2.  Manipulating natural product biosynthetic pathways via DNA assembler.

Authors:  Zengyi Shao; Huimin Zhao
Journal:  Curr Protoc Chem Biol       Date:  2014-06-03

3.  Minimal polyketide pathway expression in an actinorhodin cluster-deleted and regulation-stimulated Streptomyces coelicolor.

Authors:  Han-Na Lee; Hye-Jin Kim; Pil Kim; Heung-Shick Lee; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2012-01-18       Impact factor: 3.346

4.  Identification of a cyclosporine-specific P450 hydroxylase gene through targeted cytochrome P450 complement (CYPome) disruption in Sebekia benihana.

Authors:  Mi-Jin Lee; Hyun-Bum Kim; Yeo Joon Yoon; Kyuboem Han; Eung-Soo Kim
Journal:  Appl Environ Microbiol       Date:  2013-01-25       Impact factor: 4.792

5.  Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold.

Authors:  Zengyi Shao; Guodong Rao; Chun Li; Zhanar Abil; Yunzi Luo; Huimin Zhao
Journal:  ACS Synth Biol       Date:  2013-08-22       Impact factor: 5.110

6.  Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor.

Authors:  Han-Na Lee; Jin-Su Kim; Pil Kim; Heung-Shick Lee; Eung-Soo Kim
Journal:  Appl Environ Microbiol       Date:  2013-04-19       Impact factor: 4.792

7.  The -omics Era- Toward a Systems-Level Understanding of Streptomyces.

Authors:  Zhan Zhou; Jianying Gu; Yi-Ling Du; Yong-Quan Li; Yufeng Wang
Journal:  Curr Genomics       Date:  2011-09       Impact factor: 2.236

Review 8.  WblA, a global regulator of antibiotic biosynthesis in Streptomyces.

Authors:  Hee-Ju Nah; Jihee Park; Sisun Choi; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258

9.  Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy.

Authors:  Ji-Hye Nah; Hye-Jin Kim; Han-Na Lee; Mi-Jin Lee; Si-Sun Choi; Eung-Soo Kim
Journal:  Biomed Res Int       Date:  2013-03-04       Impact factor: 3.411

10.  Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster.

Authors:  Yunzi Luo; Hua Huang; Jing Liang; Meng Wang; Lu Lu; Zengyi Shao; Ryan E Cobb; Huimin Zhao
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  10 in total

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