| Literature DB >> 20189100 |
Yulia V Gerasimova1, Dmitry M Kolpashchikov.
Abstract
Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Year: 2010 PMID: 20189100 PMCID: PMC2890288 DOI: 10.1016/j.chembiol.2010.02.003
Source DB: PubMed Journal: Chem Biol ISSN: 1074-5521