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Literature DB >> 27620365

DNA Antenna Tile-Associated Deoxyribozyme Sensor with Improved Sensitivity.

Amanda J Cox^1,2, Hillary N Bengtson^1,2, Yulia V Gerasimova¹, Kyle H Rohde², Dmitry M Kolpashchikov^3,4,5.

Abstract

Some natural enzymes increase the rate of diffusion-limited reactions by facilitating substrate flow to their active sites. Inspired by this natural phenomenon, we developed a strategy for efficient substrate delivery to a deoxyribozyme (DZ) catalytic sensor. This resulted in a three- to fourfold increase in sensitivity and up to a ninefold improvement in the detection limit. The reported strategy can be used to enhance catalytic efficiency of diffusion-limited enzymes and to improve sensitivity of enzyme-based biosensors.

Entities: Chemical Disease Species

Keywords: DNA crossover tile; deoxyribozymes; diffusion-limited reactions; mycobacterium tuberculosis; split hybridization probes

Mesh：

Substances：
DNA, Catalytic
DNA

Year: 2016 PMID： 27620365 PMCID： PMC5156317 DOI： 10.1002/cbic.201600438

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

61 in total

1. Catalytic beacons for the detection of DNA and telomerase activity.

Authors: Yi Xiao; Valeri Pavlov; Tamara Niazov; Arnon Dishon; Moshe Kotler; Itamar Willner
Journal: J Am Chem Soc Date: 2004-06-23 Impact factor: 15.419

2. DNAzyme molecular beacon probes for target-induced signal-amplifying colorimetric detection of nucleic acids.

Authors: Rongzhan Fu; Taihua Li; Soo Suk Lee; Hyun Gyu Park
Journal: Anal Chem Date: 2010-12-15 Impact factor: 6.986

3. DNAzyme switches for molecular computation and signal amplification.

Authors: Simon M Bone; Nicole E Lima; Alison V Todd
Journal: Biosens Bioelectron Date: 2015-03-31 Impact factor: 10.618

4. Toehold-mediated nonenzymatic DNA strand displacement as a platform for DNA genotyping.

Authors: Dmitriy A Khodakov; Anastasia S Khodakova; Adrian Linacre; Amanda V Ellis
Journal: J Am Chem Soc Date: 2013-04-03 Impact factor: 15.419

5. Cellular uptake, distribution, and stability of 10-23 deoxyribozymes.

Authors: Crispin R Dass; Edward G Saravolac; Yang Li; Lun-Quan Sun
Journal: Antisense Nucleic Acid Drug Dev Date: 2002-10

6. A model study of sequential enzyme reactions and electrostatic channeling.

Authors: Changsun Eun; Peter M Kekenes-Huskey; Vincent T Metzger; J Andrew McCammon
Journal: J Chem Phys Date: 2014-03-14 Impact factor: 3.488

Review 7. Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes.

Authors: Scott K Silverman
Journal: Trends Biochem Sci Date: 2016-05-25 Impact factor: 13.807

8. A differential fluorescent receptor for nucleic acid analysis.

Authors: Hillary N Bengtson; Dmitry M Kolpashchikov
Journal: Chembiochem Date: 2013-12-11 Impact factor: 3.164

9. Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA.

Authors: Dmitriy A Khodakov; Anastasia S Khodakova; David M Huang; Adrian Linacre; Amanda V Ellis
Journal: Sci Rep Date: 2015-03-04 Impact factor: 4.379

10. In vivo co-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner.

Authors: Gairik Sachdeva; Abhishek Garg; David Godding; Jeffrey C Way; Pamela A Silver
Journal: Nucleic Acids Res Date: 2014-07-17 Impact factor: 16.971

6 in total

DNA Antenna Tile-Associated Deoxyribozyme Sensor with Improved Sensitivity.

1. Catalytic beacons for the detection of DNA and telomerase activity.

2. DNAzyme molecular beacon probes for target-induced signal-amplifying colorimetric detection of nucleic acids.

3. DNAzyme switches for molecular computation and signal amplification.

4. Toehold-mediated nonenzymatic DNA strand displacement as a platform for DNA genotyping.

5. Cellular uptake, distribution, and stability of 10-23 deoxyribozymes.

6. A model study of sequential enzyme reactions and electrostatic channeling.

Review 7. Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes.

8. A differential fluorescent receptor for nucleic acid analysis.

9. Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA.

10. In vivo co-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner.

1. FaptaSyme: A Strategy for Converting a Monomer/Oligomer-Nonselective Aptameric Sensor into an Oligomer-Selective One.

2. DNA nanotechnology for nucleic acid analysis: multifunctional molecular DNA machine for RNA detection.

3. Multiplex detection of extensively drug resistant tuberculosis using binary deoxyribozyme sensors.

4. A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids.

5. Divide and Control: Comparison of Split and Switch Hybridization Sensors.

6. A smart deoxyribozyme-based fluorescent sensor for in vitro detection of androgen receptor mRNA.