BACKGROUND: Structural and functional brain imaging studies suggest abnormalities of the amygdala and hippocampus in posttraumatic stress disorder and major depressive disorder. However, structural brain imaging studies in social phobia are lacking. METHODS: In total, 24 patients with generalized social phobia (GSP) and 24 healthy controls underwent3-dimensional structural magnetic resonance imaging of the amygdala and hippocampus and a clinical investigation. RESULTS: Compared with controls, GSP patients had significantly reduced amygdalar (13%) and hippocampal (8%) size. The reduction in the size of the amygdala was statistically significant for men but not women. Smaller right-sided hippocampal volumes of GSP patients were significantly related to stronger disorder severity. LIMITATIONS: Our sample included only patients with the generalized subtype of social phobia. Because we excluded patients with comorbid depression, our sample may not be representative. CONCLUSION: We report for the first time volumetric results in patients with GSP. Future assessment of these patients will clarify whether these changes are reversed after successful treatment and whether they predict treatment response.
RCT Entities:
BACKGROUND: Structural and functional brain imaging studies suggest abnormalities of the amygdala and hippocampus in posttraumatic stress disorder and major depressive disorder. However, structural brain imaging studies in social phobia are lacking. METHODS: In total, 24 patients with generalized social phobia (GSP) and 24 healthy controls underwent 3-dimensional structural magnetic resonance imaging of the amygdala and hippocampus and a clinical investigation. RESULTS: Compared with controls, GSP patients had significantly reduced amygdalar (13%) and hippocampal (8%) size. The reduction in the size of the amygdala was statistically significant for men but not women. Smaller right-sided hippocampal volumes of GSP patients were significantly related to stronger disorder severity. LIMITATIONS: Our sample included only patients with the generalized subtype of social phobia. Because we excluded patients with comorbid depression, our sample may not be representative. CONCLUSION: We report for the first time volumetric results in patients with GSP. Future assessment of these patients will clarify whether these changes are reversed after successful treatment and whether they predict treatment response.
Authors: A Barrós-Loscertales; V Meseguer; A Sanjuán; V Belloch; M A Parcet; R Torrubia; C Avila Journal: Neuroimage Date: 2006-09-18 Impact factor: 6.556
Authors: Anke Karl; Michael Schaefer; Loretta S Malta; Denise Dörfel; Nicolas Rohleder; Annett Werner Journal: Neurosci Biobehav Rev Date: 2006-05-26 Impact factor: 8.989
Authors: Warren D Taylor; David C Steffens; Martha E Payne; James R MacFall; Douglas A Marchuk; Ingrid K Svenson; K Ranga R Krishnan Journal: Arch Gen Psychiatry Date: 2005-05
Authors: Thomas Frodl; Markus Jäger; Ivana Smajstrlova; Christine Born; Ronald Bottlender; Tanja Palladino; Maximilian Reiser; Hans-Jürgen Möller; Eva M Meisenzahl Journal: J Psychiatry Neurosci Date: 2008-09 Impact factor: 6.186
Authors: Karina Blair; Jonathan Shaywitz; Bruce W Smith; Rebecca Rhodes; Marilla Geraci; Matthew Jones; Daniel McCaffrey; Meena Vythilingam; Elizabeth Finger; Krystal Mondillo; Madeline Jacobs; Dennis S Charney; R J R Blair; Wayne C Drevets; Daniel S Pine Journal: Am J Psychiatry Date: 2008-05-15 Impact factor: 18.112
Authors: Jens Foell; Isabella M Palumbo; James R Yancey; Nathalie Vizueta; Traute Demirakca; Christopher J Patrick Journal: Neuroimage Date: 2018-10-28 Impact factor: 6.556
Authors: Celia van der Merwe; Neda Jahanshad; Josh W Cheung; Mary Mufford; Nynke A Groenewold; Nastassja Koen; Rajkumar Ramesar; Shareefa Dalvie; James A Knowles; Derrek P Hibar; Caroline M Nievergelt; Karestan C Koenen; Israel Liberzon; Kerry J Ressler; Sarah E Medland; Rajendra A Morey; Paul M Thompson; Dan J Stein Journal: J Affect Disord Date: 2018-11-13 Impact factor: 4.839
Authors: Kirsten Tillisch; Emeran A Mayer; Arpana Gupta; Zafar Gill; Rémi Brazeilles; Boris Le Nevé; Johan E T van Hylckama Vlieg; Denis Guyonnet; Muriel Derrien; Jennifer S Labus Journal: Psychosom Med Date: 2017-10 Impact factor: 4.312
Authors: Orlin S Todorov; Vera Weisbecker; Emmanuel Gilissen; Karl Zilles; Alexandra A de Sousa Journal: Proc Biol Sci Date: 2019-10-30 Impact factor: 5.349
Authors: Andrea L Gold; Elizabeth R Steuber; Lauren K White; Jennifer Pacheco; Jessica F Sachs; David Pagliaccio; Erin Berman; Ellen Leibenluft; Daniel S Pine Journal: Neuropsychopharmacology Date: 2017-04-24 Impact factor: 7.853
Authors: Mazen A Kheirbek; Liam J Drew; Nesha S Burghardt; Daniel O Costantini; Lindsay Tannenholz; Susanne E Ahmari; Hongkui Zeng; André A Fenton; René Hen Journal: Neuron Date: 2013-03-06 Impact factor: 17.173