Literature DB >> 20165875

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).

Simone S Grecco1, Juliana Q Reimão, Andre G Tempone, Patricia Sartorelli, Paulete Romoff, Marcelo J P Ferreira, Oriana A Fávero, Joao H G Lago.   

Abstract

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.

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Year:  2010        PMID： 20165875     DOI： 10.1007/s00436-010-1771-8

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  18 in total

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