Literature DB >> 9580315

The pharmacology of leishmaniasis.

R Balaña-Fouce1, R M Reguera, J C Cubría, D Ordóñez.   

Abstract

The development of new strategies on chemotherapy of parasitic protozoan diseases is one of the most exciting research fields of recent years. World Health Organization (WHO) reports have recognized that the physiology and biochemistry of protozoan parasites and the host-parasite relation are the main targets for the design of new drugs that can be used in the future against these diseases.

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Year:  1998        PMID： 9580315     DOI： 10.1016/s0306-3623(97)00268-1

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  26 in total

1.  N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide.

Authors:  C Chicharro; C Granata; R Lozano; D Andreu; L Rivas
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

2.  Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

Authors:  Tatiana Y Hargrove; Zdzislaw Wawrzak; Jialin Liu; W David Nes; Michael R Waterman; Galina I Lepesheva
Journal:  J Biol Chem       Date:  2011-05-31       Impact factor: 5.157

3.  Synthesis and antileishmanial activities of novel 3-substituted quinolines.

Authors:  André Gustavo Tempone; Ana Cláudia Melo Pompeu da Silva; Carlos Alberto Brandt; Fernanda Scalzaretto Martinez; Samanta Etel Treiger Borborema; Maria Amélia Barata da Silveira; Heitor Franco de Andrade
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

4.  Efficacy of combined therapy with liposome-encapsulated meglumine antimoniate and allopurinol in treatment of canine visceral leishmaniasis.

Authors:  Sydnei M da Silva; Izabela F G Amorim; Raul R Ribeiro; Erly G Azevedo; Cynthia Demicheli; Maria N Melo; Wagner L Tafuri; Nelder F Gontijo; Marilene S M Michalick; Frédéric Frézard
Journal:  Antimicrob Agents Chemother       Date:  2012-03-12       Impact factor: 5.191

5.  Enhanced activity of antisense phosphorothioate oligos against leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions.

Authors:  M Mishra; J M Porter-Kelley; P K Singh; J R Bennett; G Chaudhuri
Journal:  Biochem Pharmacol       Date:  2001-09-01       Impact factor: 5.858

6.  Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae).

Authors:  Patrícia Sartorelli; Camila Salomone Carvalho; Juliana Quero Reimão; Marcelo José Pena Ferreira; André Gustavo Tempone
Journal:  Parasitol Res       Date:  2008-09-23       Impact factor: 2.289

7.  Total synthesis and antileishmanial activity of the natural occurring acetylenic fatty acids 6-heptadecynoic acid and 6-icosynoic acid.

Authors:  Néstor M Carballeira; Michelle M Cartagena; Christopher Fernández Prada; Celia Fernández Rubio; Rafael Balaña-Fouce
Journal:  Lipids       Date:  2009-09-30       Impact factor: 1.880

8.  Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes.

Authors:  Juan Román Luque-Ortega; Silvia Martínez; José María Saugar; Laura R Izquierdo; Teresa Abad; Javier G Luis; José Piñero; Basilio Valladares; Luis Rivas
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

9.  Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.

Authors:  Rafael Balaña-Fouce; Christopher F Prada; José María Requena; Mark Cushman; Yves Pommier; Raquel Álvarez-Velilla; José Miguel Escudero-Martínez; Estefania Calvo-Álvarez; Yolanda Pérez-Pertejo; Rosa M Reguera
Journal:  Antimicrob Agents Chemother       Date:  2012-07-30       Impact factor: 5.191

10.  Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole.

Authors:  Juliana Tonini Mesquita; Thais Alves da Costa-Silva; Samanta Etel Treiger Borborema; André Gustavo Tempone
Journal:  Mol Cell Biochem       Date:  2013-12-29       Impact factor: 3.396
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