Literature DB >> 19489596

Antileishmaniasis activity of flavonoids from Consolida oliveriana.

Clotilde Marín1, Samira Boutaleb-Charki, Jesús G Díaz, Oscar Huertas, María J Rosales, Gregorio Pérez-Cordon, Ramon Guitierrez-Sánchez, Manuel Sánchez-Moreno.   

Abstract

A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19489596     DOI： 10.1021/np8008122

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase.

Authors:  Lucas A Chibli; Annylory L Rosa; Maria Cristina Nonato; Fernando B Da Costa
Journal:  Metabolomics       Date:  2019-04-04       Impact factor: 4.290

2.  Library of Seleno-Compounds as Novel Agents against Leishmania Species.

Authors:  Álvaro Martín-Montes; Daniel Plano; Rubén Martín-Escolano; Verónica Alcolea; Marta Díaz; Silvia Pérez-Silanes; Socorro Espuelas; Esther Moreno; Clotilde Marín; Ramón Gutiérrez-Sánchez; Carmen Sanmartín; Manuel Sánchez-Moreno
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

3.  Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum.

Authors:  Paula S Lage; Miguel A Chávez-Fumagalli; Juliana T Mesquita; Laís M Mata; Simone O A Fernandes; Valbert N Cardoso; Manuel Soto; Carlos A P Tavares; João P V Leite; Andre G Tempone; Eduardo A F Coelho
Journal:  Parasitol Res       Date:  2015-09-07       Impact factor: 2.289

4.  Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).

Authors:  Simone S Grecco; Juliana Q Reimão; Andre G Tempone; Patricia Sartorelli; Paulete Romoff; Marcelo J P Ferreira; Oriana A Fávero; Joao H G Lago
Journal:  Parasitol Res       Date:  2010-02-18       Impact factor: 2.289

5.  Leishmanicidal activity of nine novel flavonoids from Delphinium staphisagria.

Authors:  Inmaculada Ramírez-Macías; Clotilde Marín; Jesús G Díaz; María José Rosales; Ramón Gutiérrez-Sánchez; Manuel Sánchez-Moreno
Journal:  ScientificWorldJournal       Date:  2012-05-22

6.  Phytochemical composition, antiparasitic and α-glucosidase inhibition activities from Pelliciera rhizophorae.

Authors:  Dioxelis López; Lilia Cherigo; Carmenza Spadafora; Marco A Loza-Mejía; Sergio Martínez-Luis
Journal:  Chem Cent J       Date:  2015-09-28       Impact factor: 4.215

Review 7.  Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.

Authors:  Aysooda Hosseinzade; Omid Sadeghi; Akram Naghdipour Biregani; Sepideh Soukhtehzari; Gabriel S Brandt; Ahmad Esmaillzadeh
Journal:  Front Immunol       Date:  2019-01-31       Impact factor: 7.561

8.  Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity.

Authors:  Paula Sousa Lage; Pedro Henrique Rocha de Andrade; Amanda de Santana Lopes; Miguel Angel Chávez Fumagalli; Diogo Garcia Valadares; Mariana Costa Duarte; Daniela Pagliara Lage; Lourena Emanuele Costa; Vivian Tamietti Martins; Tatiana Gomes Ribeiro; José Dias de Souza Filho; Carlos Alberto Pereira Tavares; Rodrigo Maia de Pádua; João Paulo Viana Leite; Eduardo Antonio Ferraz Coelho
Journal:  Evid Based Complement Alternat Med       Date:  2013-09-30       Impact factor: 2.629

9.  Effect of Aqueous Allium cepa and Ixora brachiata Root Extract on Leishmania major Promastigotes.

Authors:  Batool Sadeghi-Nejad; Jasem Saki
Journal:  Jundishapur J Nat Pharm Prod       Date:  2014-04-24

10.  Antileishmanial, toxicity, and phytochemical evaluation of medicinal plants collected from Pakistan.

Authors:  Naseer Ali Shah; Muhammad Rashid Khan; Akhtar Nadhman
Journal:  Biomed Res Int       Date:  2014-05-19       Impact factor: 3.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.