Literature DB >> 19540316

In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).

A A da Silva Filho1, D O Resende, M J Fukui, F F Santos, P M Pauletti, W R Cunha, M L A Silva, L E Gregório, J K Bastos, N P D Nanayakkara.   

Abstract

Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).

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Year:  2009        PMID： 19540316     DOI： 10.1016/j.fitote.2009.06.007

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  20 in total

1.  In vitro antileishmanial and antitrypanosomal activities of five medicinal plants from Burkina Faso.

Authors:  W R Sawadogo; G Le Douaron; A Maciuk; C Bories; P M Loiseau; B Figadère; I P Guissou; O G Nacoulma
Journal:  Parasitol Res       Date:  2011-10-25       Impact factor: 2.289

2.  Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice.

Authors:  Eduardo Seiji Yamamoto; Bruno Luiz S Campos; Márcia Dalastra Laurenti; João H G Lago; Simone dos Santos Grecco; Carlos E P Corbett; Luiz Felipe D Passero
Journal:  Parasitol Res       Date:  2013-10-31       Impact factor: 2.289

3.  Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India.

Authors:  Chinnaperumal Kamaraj; Naveen Kumar Kaushik; Dinesh Mohanakrishnan; Gandhi Elango; Asokan Bagavan; Abdul Abduz Zahir; Abdul Abdul Rahuman; Dinkar Sahal
Journal:  Parasitol Res       Date:  2011-06-04       Impact factor: 2.289

4.  Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae).

Authors:  Luiz Felipe D Passero; Alexis Bonfim-Melo; Carlos Eduardo P Corbett; Márcia D Laurenti; Marcos H Toyama; Daniela O de Toyama; Paulete Romoff; Oriana A Fávero; Simone S dos Grecco; Cynthia A Zalewsky; João Henrique G Lago
Journal:  Parasitol Res       Date:  2010-10-01       Impact factor: 2.289

5.  Association of water extract of green propolis and liposomal meglumine antimoniate in the treatment of experimental visceral leishmaniasis.

Authors:  Flávia M Ferreira; Renata A O Castro; Mauricio A Batista; Fernanda M O Rossi; Denise Silveira-Lemos; Frédéric Frézard; Sandra A L Moura; Simone A Rezende
Journal:  Parasitol Res       Date:  2013-11-30       Impact factor: 2.289

Review 6.  Stevia Genus: Phytochemistry and Biological Activities Update.

Authors:  Jimena Borgo; Laura C Laurella; Florencia Martini; Cesar A N Catalán; Valeria P Sülsen
Journal:  Molecules       Date:  2021-05-06       Impact factor: 4.411

7.  In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms.

Authors:  Lizandra G Magalhães; Govind J Kapadia; Lígia R da Silva Tonuci; Soraya C Caixeta; Natállia A Parreira; Vanderlei Rodrigues; Ademar A Da Silva Filho
Journal:  Parasitol Res       Date:  2009-11-07       Impact factor: 2.289

8.  Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).

Authors:  Simone S Grecco; Juliana Q Reimão; Andre G Tempone; Patricia Sartorelli; Paulete Romoff; Marcelo J P Ferreira; Oriana A Fávero; Joao H G Lago
Journal:  Parasitol Res       Date:  2010-02-18       Impact factor: 2.289

9.  Evaluation of antileishmanial activity of selected brazilian plants and identification of the active principles.

Authors:  Valdir Cechinel Filho; Christiane Meyre-Silva; Rivaldo Niero; Luisa Nathália Bolda Mariano; Fabiana Gomes do Nascimento; Ingrid Vicente Farias; Vanessa Fátima Gazoni; Bruna Dos Santos Silva; Alberto Giménez; David Gutierrez-Yapu; Efrain Salamanca; Angela Malheiros
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-09       Impact factor: 2.629

Review 10.  Malaria in South America: a drug discovery perspective.

Authors:  Luiza R Cruz; Thomas Spangenberg; Marcus V G Lacerda; Timothy N C Wells
Journal:  Malar J       Date:  2013-05-24       Impact factor: 2.979
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