Literature DB >> 20161946

Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin.

Kunchithapatham Janakiraman1, Rajappan Manavalan.   

Abstract

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.

Entities:  

Keywords:  Ampicillin; Bioavailability; Norfloxacin; Phamacokinetics; Piper nigrum; Piperine

Year:  2008        PMID： 20161946      PMCID： PMC2816554          DOI： 10.4314/ajtcam.v5i3.31281

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  12 in total

1.  Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers.

Authors:  G Bano; R K Raina; U Zutshi; K L Bedi; R K Johri; S C Sharma
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

2.  Effect of piperine on pentobarbitone induced hypnosis in rats.

Authors:  A M Mujumdar; J N Dhuley; V K Deshmukh; P H Raman; S L Thorat; S R Naik
Journal:  Indian J Exp Biol       Date:  1990-05       Impact factor: 0.818

3.  Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.

Authors:  C K Atal; U Zutshi; P G Rao
Journal:  J Ethnopharmacol       Date:  1981-09       Impact factor: 4.360

4.  Postcoital antifertility effect of piperine.

Authors:  P Piyachaturawat; T Glinsukon; P Peugvicha
Journal:  Contraception       Date:  1982-12       Impact factor: 3.375

5.  Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.

Authors:  Rajinder K Bhardwaj; Hartmut Glaeser; Laurent Becquemont; Ulrich Klotz; Suresh K Gupta; Martin F Fromm
Journal:  J Pharmacol Exp Ther       Date:  2002-08       Impact factor: 4.030

6.  Inhibition of lipid peroxidation by piperine during experimental inflammation in rats.

Authors:  J N Dhuley; P H Raman; A M Mujumdar; S R Naik
Journal:  Indian J Exp Biol       Date:  1993-05       Impact factor: 0.818

7.  Anti-inflammatory activity of piperine.

Authors:  A M Mujumdar; J N Dhuley; V K Deshmukh; P H Raman; S R Naik
Journal:  Jpn J Med Sci Biol       Date:  1990-06

8.  Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

Authors:  G Shoba; D Joy; T Joseph; M Majeed; R Rajendran; P S Srinivas
Journal:  Planta Med       Date:  1998-05       Impact factor: 3.352

9.  Piperine-mediated changes in the permeability of rat intestinal epithelial cells. The status of gamma-glutamyl transpeptidase activity, uptake of amino acids and lipid peroxidation.

Authors:  R K Johri; N Thusu; A Khajuria; U Zutshi
Journal:  Biochem Pharmacol       Date:  1992-04-01       Impact factor: 5.858

10.  Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.

Authors:  A R Hiwale; J N Dhuley; S R Naik
Journal:  Indian J Exp Biol       Date:  2002-03       Impact factor: 0.818
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  3 in total

1.  Bioenhancers from mother nature and their applicability in modern medicine.

Authors:  Gurpreet Kaur Randhawa; Jagdev Singh Kullar
Journal:  Int J Appl Basic Med Res       Date:  2011-01

Review 2.  A comprehensive review on pharmacotherapeutics of herbal bioenhancers.

Authors:  Ghanshyam B Dudhatra; Shailesh K Mody; Madhavi M Awale; Hitesh B Patel; Chirag M Modi; Avinash Kumar; Divyesh R Kamani; Bhavesh N Chauhan
Journal:  ScientificWorldJournal       Date:  2012-09-17

3.  PRE-CLINICAL EVALUATION OF EXTRACTS AND ESSENTIAL OILS FROM BETEL-LIKE SCENT PIPER SPECIES IDENTIFIED POTENTIAL CANCER TREATMENT.

Authors:  Arisa Sanubol; Arunrat Chaveerach; Tawatchai Tanee; Runglawan Sudmoon
Journal:  Afr J Tradit Complement Altern Med       Date:  2016-11-23
  3 in total

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