| Literature DB >> 12635696 |
A R Hiwale1, J N Dhuley, S R Naik.
Abstract
Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.Entities:
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Year: 2002 PMID： 12635696
Source DB: PubMed Journal: Indian J Exp Biol ISSN： 0019-5189 Impact factor: 0.818