Literature DB >> 20146518

Photo-cross-linked PDMSstar-PEG hydrogels: synthesis, characterization, and potential application for tissue engineering scaffolds.

Yaping Hou1, Cody A Schoener, Katherine R Regan, Dany Munoz-Pinto, Mariah S Hahn, Melissa A Grunlan.   

Abstract

Inorganic-organic hydrogels with tunable chemical and physical properties were prepared from methacrylated star polydimethylsiloxane (PDMS(star)-MA) and diacrylated poly(ethylene glycol) (PEG-DA) for use as tissue engineering scaffolds. A total of 18 compositionally unique hydrogels were prepared by photo-cross-linking, varying weight ratios of PEG-DA and PDMS(star)-MA of different molecular weights (M(n)): PEG-DA (M(n) = 3.4k and 6k g/mol) and PDMS(star)-MA (M(n) = 1.8k, 5k, and 7k g/mol). Introduction of PDMS(star)-MA caused formation of discrete PDMS-enriched microparticles dispersed within the PEG matrix. The swelling ratio, mechanical properties in tension and compression, nonspecific protein adhesion, controlled introduction of bioactivity, and cytotoxicity of hydrogels were studied. This library of inorganic-organic hydrogels with tunable properties provides a useful platform to study the effect of scaffold properties on cell behavior.

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Year:  2010        PMID： 20146518      PMCID： PMC2842009          DOI： 10.1021/bm9012293

Source DB:  PubMed          Journal:  Biomacromolecules        ISSN： 1525-7797            Impact factor:   6.988


  49 in total

Review 1.  Biodegradable polymeric scaffolds for musculoskeletal tissue engineering.

Authors:  C M Agrawal; R B Ray
Journal:  J Biomed Mater Res       Date:  2001-05

Review 2.  Hydrogels in pharmaceutical formulations.

Authors:  N A Peppas; P Bures; W Leobandung; H Ichikawa
Journal:  Eur J Pharm Biopharm       Date:  2000-07       Impact factor: 5.571

Review 3.  Hydrogels for tissue engineering.

Authors:  K Y Lee; D J Mooney
Journal:  Chem Rev       Date:  2001-07       Impact factor: 60.622

4.  Proliferation and differentiation of goat bone marrow stromal cells in 3D scaffolds with tunable hydrophilicity.

Authors:  J L Escobar Ivirico; M Salmerón-Sánchez; J L Gómez Ribelles; M Monleón Pradas; J M Soria; M E Gomes; R L Reis; J F Mano
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2009-10       Impact factor: 3.368

5.  Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks.

Authors:  J Elisseeff; W McIntosh; K Anseth; S Riley; P Ragan; R Langer
Journal:  J Biomed Mater Res       Date:  2000-08

6.  Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels.

Authors:  Stephanie J Bryant; Kristi S Anseth
Journal:  J Biomed Mater Res       Date:  2002-01

7.  Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering.

Authors:  B K Mann; A S Gobin; A T Tsai; R H Schmedlen; J L West
Journal:  Biomaterials       Date:  2001-11       Impact factor: 12.479

8.  Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro.

Authors:  S J Bryant; C R Nuttelman; K S Anseth
Journal:  J Biomater Sci Polym Ed       Date:  2000       Impact factor: 3.517

9.  The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels.

Authors:  S J Bryant; K S Anseth
Journal:  Biomaterials       Date:  2001-03       Impact factor: 12.479

10.  Osteoblast response to dimethacrylate composites varying in composition, conversion and roughness using a combinatorial approach.

Authors:  Nancy J Lin; Sheng Lin-Gibson
Journal:  Biomaterials       Date:  2009-06-10       Impact factor: 12.479
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  23 in total

1.  In situ tissue engineering using magnetically guided three-dimensional cell patterning.

Authors:  Shawn P Grogan; Chantal Pauli; Peter Chen; Jiang Du; Christine B Chung; Seong Deok Kong; Clifford W Colwell; Martin K Lotz; Sungho Jin; Darryl D D'Lima
Journal:  Tissue Eng Part C Methods       Date:  2012-02-10       Impact factor: 3.056

Review 2.  Designing degradable hydrogels for orthogonal control of cell microenvironments.

Authors:  Prathamesh M Kharkar; Kristi L Kiick; April M Kloxin
Journal:  Chem Soc Rev       Date:  2013-04-22       Impact factor: 54.564

3.  Synthetically simple, highly resilient hydrogels.

Authors:  Jun Cui; Melissa A Lackey; Ahmad E Madkour; Erika M Saffer; David M Griffin; Surita R Bhatia; Alfred J Crosby; Gregory N Tew
Journal:  Biomacromolecules       Date:  2012-02-28       Impact factor: 6.988

4.  Incorporation of a silicon-based polymer to PEG-DA templated hydrogel scaffolds for bioactivity and osteoinductivity.

Authors:  Michael T Frassica; Sarah K Jones; Patricia Diaz-Rodriguez; Mariah S Hahn; Melissa A Grunlan
Journal:  Acta Biomater       Date:  2019-09-16       Impact factor: 8.947

5.  Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels.

Authors:  Quynhhoa T Nguyen; Yongsung Hwang; Albert C Chen; Shyni Varghese; Robert L Sah
Journal:  Biomaterials       Date:  2012-06-30       Impact factor: 12.479

6.  Amphiphilic Interpenetrating Networks for the Delivery of Hydrophobic, Low Molecular Weight Therapeutic Agents.

Authors:  Cody A Schoener; Heather N Hutson; Grace K Fletcher; Nicholas A Peppas
Journal:  Ind Eng Chem Res       Date:  2011-11-16       Impact factor: 3.720

7.  Cyclic alternating ring-opening metathesis polymerization (CAROMP). Rapid access to functionalized cyclic polymers.

Authors:  Airong Song; Kathlyn A Parker; Nicole S Sampson
Journal:  Org Lett       Date:  2010-09-03       Impact factor: 6.005

8.  Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells.

Authors:  Patricia Diaz-Rodriguez; Josh D Erndt-Marino; Tanmay Gharat; Dany J Munoz Pinto; Satyavrata Samavedi; Robert Bearden; Melissa A Grunlan; W Brian Saunders; Mariah S Hahn
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2018-12-13       Impact factor: 3.368

9.  Continuous gradient scaffolds for rapid screening of cell-material interactions and interfacial tissue regeneration.

Authors:  Brennan M Bailey; Lindsay N Nail; Melissa A Grunlan
Journal:  Acta Biomater       Date:  2013-05-22       Impact factor: 8.947

10.  Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds.

Authors:  L A Hockaday; K H Kang; N W Colangelo; P Y C Cheung; B Duan; E Malone; J Wu; L N Girardi; L J Bonassar; H Lipson; C C Chu; J T Butcher
Journal:  Biofabrication       Date:  2012-08-23       Impact factor: 9.954
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