Literature DB >> 2012390

Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.

J A Detre1, Z Y Wang, A R Bogdan, D A Gusnard, C A Bay, P M Bingham, R A Zimmerman.   

Abstract

Localized water-suppressed 1H magnetic resonance spectroscopy was performed in an 11-month-old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalities were seen with routine T2-weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.

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Year:  1991        PMID： 2012390     DOI： 10.1002/ana.410290219

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  16 in total

1.  Regional metabolite levels of the normal posterior fossa studied by proton chemical shift imaging.

Authors:  D Galanaud; Y Le Fur; F Nicoli; B Denis; S Confort-Gouny; J P Ranjeva; P Viout; J Pelletier; P J Cozzone
Journal:  MAGMA       Date:  2001-10       Impact factor: 2.310

Review 2.  The role of magnetic resonance spectroscopy in the investigation of lactic acidosis and inborn errors of energy metabolism.

Authors:  D G Gadian; J V Leonard
Journal:  J Inherit Metab Dis       Date:  1996       Impact factor: 4.982

3.  Diagnostic and prognostic value of in vivo proton MR spectroscopy for Zellweger syndrome spectrum patients.

Authors:  H Rosewich; P Dechent; C Krause; A Ohlenbusch; K Brockmann; J Gärtner
Journal:  J Inherit Metab Dis       Date:  2016-08-03       Impact factor: 4.982

Review 4.  MR spectroscopy in children: protocols and pitfalls in non-tumorous brain pathology.

Authors:  Jacques F Schneider
Journal:  Pediatr Radiol       Date:  2016-05-27

5.  The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T ¹H-MRS study.

Authors:  Kejia Cai; Ravi Pr Nanga; Lisa Lamprou; Claudia Schinstine; Mark Elliott; Hari Hariharan; Ravinder Reddy; C Neill Epperson
Journal:  Neuropsychopharmacology       Date:  2012-08-08       Impact factor: 7.853

Review 6.  What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy?

Authors:  J Vion-Dury; D J Meyerhoff; P J Cozzone; M W Weiner
Journal:  J Neurol       Date:  1994-05       Impact factor: 4.849

Review 7.  Pediatric neurodegenerative white matter processes: leukodystrophies and beyond.

Authors:  Jonathan A Phelan; Lisa H Lowe; Charles M Glasier
Journal:  Pediatr Radiol       Date:  2008-04-30

8.  Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders.

Authors:  J H Cross; D G Gadian; A Connelly; J V Leonard
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

9.  MRI and 1H MRS findings in Smith-Lemli-Opitz syndrome.

Authors:  P A Caruso; T Y Poussaint; A A Tzika; D Zurakowski; L G Astrakas; E R Elias; C Bay; M B Irons
Journal:  Neuroradiology       Date:  2003-11-05       Impact factor: 2.804

10.  Lesional perfusion abnormalities in Leigh disease demonstrated by arterial spin labeling correlate with disease activity.

Authors:  Matthew T Whitehead; Bonmyong Lee; Andrea Gropman
Journal:  Pediatr Radiol       Date:  2016-04-04
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