Literature DB >> 8884578

The role of magnetic resonance spectroscopy in the investigation of lactic acidosis and inborn errors of energy metabolism.

D G Gadian1, J V Leonard.   

Abstract

Magnetic resonance spectroscopy (MRS) provides a non-invasive method of investigating disordered energy metabolism in vivo. Here, we briefly outline some MRS studies of skeletal muscle and brain metabolism that have been carried out in patients with inborn errors of energy metabolism. We concentrate in particular on the use of 1H MRS for the detection of elevated brain lactate in these patients.

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Year:  1996        PMID： 8884578     DOI： 10.1007/bf01799115

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  21 in total

1.  Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.

Authors:  J A Detre; Z Y Wang; A R Bogdan; D A Gusnard; C A Bay; P M Bingham; R A Zimmerman
Journal:  Ann Neurol       Date:  1991-02       Impact factor: 10.422

2.  Examination of a case of suspected McArdle's syndrome by 31P nuclear magnetic resonance.

Authors:  B D Ross; G K Radda; D G Gadian; G Rocker; M Esiri; J Falconer-Smith
Journal:  N Engl J Med       Date:  1981-05-28       Impact factor: 91.245

3.  31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle.

Authors:  S Eleff; N G Kennaway; N R Buist; V M Darley-Usmar; R A Capaldi; W J Bank; B Chance
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

4.  High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.

Authors:  K L Behar; J A den Hollander; M E Stromski; T Ogino; R G Shulman; O A Petroff; J W Prichard
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

5.  Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro.

Authors:  J Urenjak; S R Williams; D G Gadian; M Noble
Journal:  J Neurochem       Date:  1992-07       Impact factor: 5.372

6.  Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.

Authors:  M S van der Knaap; J van der Grond; P C van Rijen; J A Faber; J Valk; K Willemse
Journal:  Radiology       Date:  1990-08       Impact factor: 11.105

7.  Immunohistochemical localization of N-acetylaspartate in rat brain.

Authors:  J R Moffett; M A Namboodiri; C B Cangro; J H Neale
Journal:  Neuroreport       Date:  1991-03       Impact factor: 1.837

8.  Unique aspects of human newborn cerebral metabolism evaluated with phosphorus nuclear magnetic resonance spectroscopy.

Authors:  D P Younkin; M Delivoria-Papadopoulos; J C Leonard; V H Subramanian; S Eleff; J S Leigh; B Chance
Journal:  Ann Neurol       Date:  1984-11       Impact factor: 10.422

9.  In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondrial disease.

Authors:  P M Matthews; C Allaire; E A Shoubridge; G Karpati; S Carpenter; D L Arnold
Journal:  Neurology       Date:  1991-01       Impact factor: 9.910

10.  Clinical diversity of pyruvate dehydrogenase deficiency.

Authors:  J H Cross; A Connelly; D G Gadian; B E Kendall; G K Brown; R M Brown; J V Leonard
Journal:  Pediatr Neurol       Date:  1994-06       Impact factor: 3.372
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