Literature DB >> 8412023

Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders.

J H Cross1, D G Gadian, A Connelly, J V Leonard.   

Abstract

Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction. Difficulties are frequently encountered in establishing a diagnosis, and the mechanisms underlying brain damage are poorly understood. We have performed proton magnetic resonance spectroscopy (1H-MRS) on 24 patients under investigation for suspected metabolic disorder, and have compared the MRS observations of brain lactate with measurements of cerebrospinal fluid (CSF) lactate. We have shown good concordance between the two types of observation, confirming the value of the CSF measurements. Regional variations in brain lactate are detected in some cases, and these may help to elucidate the mechanisms underlying selective brain damage.

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Year:  1993        PMID： 8412023     DOI： 10.1007/bf00711912

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  14 in total

1.  Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.

Authors:  J A Detre; Z Y Wang; A R Bogdan; D A Gusnard; C A Bay; P M Bingham; R A Zimmerman
Journal:  Ann Neurol       Date:  1991-02       Impact factor: 10.422

2.  In vivo proton spectroscopy in presence of eddy currents.

Authors:  U Klose
Journal:  Magn Reson Med       Date:  1990-04       Impact factor: 4.668

3.  Blood sampling technique for lactate and pyruvate estimation in children.

Authors:  L A Kollée; J L Willems; A F de Kort; L A Monnens; J M Trijbels
Journal:  Ann Clin Biochem       Date:  1977-09       Impact factor: 2.057

Review 4.  Disorders of the mitochondrial respiratory chain: clinical manifestations and diagnostic approach.

Authors:  J M Trijbels; R C Sengers; W Ruitenbeek; J C Fischer; J A Bakkeren; A J Janssen
Journal:  Eur J Pediatr       Date:  1988-11       Impact factor: 3.183

5.  Sedation in children scanned with high-field magnetic resonance; the experience at the Hospital for Sick Children, Great Ormond Street.

Authors:  J K Shepherd; M A Hall-Craggs; J P Finn; R M Bingham
Journal:  Br J Radiol       Date:  1990-10       Impact factor: 3.039

6.  Metabolic imaging of patients with intracranial tumors: H-1 MR spectroscopic imaging and PET.

Authors:  P R Luyten; A J Marien; W Heindel; P H van Gerwen; K Herholz; J A den Hollander; G Friedmann; W D Heiss
Journal:  Radiology       Date:  1990-09       Impact factor: 11.105

7.  Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro.

Authors:  J Urenjak; S R Williams; D G Gadian; M Noble
Journal:  J Neurochem       Date:  1992-07       Impact factor: 5.372

8.  Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.

Authors:  M S van der Knaap; J van der Grond; P C van Rijen; J A Faber; J Valk; K Willemse
Journal:  Radiology       Date:  1990-08       Impact factor: 11.105

9.  Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites.

Authors:  J Frahm; H Bruhn; M L Gyngell; K D Merboldt; W Hänicke; R Sauter
Journal:  Magn Reson Med       Date:  1989-07       Impact factor: 4.668

10.  "Cerebral" lactic acidosis: defects in pyruvate metabolism with profound brain damage and minimal systemic acidosis.

Authors:  G K Brown; E A Haan; D M Kirby; R D Scholem; J E Wraith; J G Rogers; D M Danks
Journal:  Eur J Pediatr       Date:  1988-01       Impact factor: 3.183
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  5 in total

Review 1.  Imaging of neurogenetic and neurometabolic disorders of childhood.

Authors:  Andrea Gropman
Journal:  Curr Neurol Neurosci Rep       Date:  2004-03       Impact factor: 5.081

Review 2.  The role of magnetic resonance spectroscopy in the investigation of lactic acidosis and inborn errors of energy metabolism.

Authors:  D G Gadian; J V Leonard
Journal:  J Inherit Metab Dis       Date:  1996       Impact factor: 4.982

3.  Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma.

Authors:  Nicole D Osier; Melody Ziari; Ava M Puccio; Samuel Poloyac; David O Okonkwo; Margaret B Minnigh; Sue R Beers; Yvette P Conley
Journal:  Brain Inj       Date:  2019-07-15       Impact factor: 2.311

4.  Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease.

Authors:  Doris D M Lin; Thomas O Crawford; Peter B Barker
Journal:  AJNR Am J Neuroradiol       Date:  2003-01       Impact factor: 3.825

5.  Brain MR imaging and proton MR spectroscopy in female mice with pyruvate dehydrogenase complex deficiency.

Authors:  Lioudmila Pliss; Richard Mazurchuk; Joseph A Spernyak; Mulchand S Patel
Journal:  Neurochem Res       Date:  2007-03-07       Impact factor: 3.996
  5 in total

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